“We are pleased that this novel Fleximer-ADC has passed yet another important milestone as it advances toward clinical development,” said
“We are very pleased to see that this novel ADC has successfully completed pilot toxicology assessments,” said
The collaboration between Mersana and Endo leverages Mersana’s proprietary conjugation technology, comprised of the Fleximer® polymer and a broad array of customizable linker chemistries for attaching diverse, potent payloads to antibodies. Under the terms of the agreement, Mersana is responsible for conducting research and creating Fleximer-ADC development candidates with antibodies provided by Endo. The rights to these ADCs have been licensed to Endo in exchange for research funding, milestone payments and royalties on worldwide net sales of any resulting ADC products.
About Fleximer® Antibody-Drug Conjugate Technology
Mersana’s next-generation Fleximer® antibody-drug conjugate (ADC) technology is based on the Company’s proprietary biodegradable polymer system, known as Fleximer®, and a wide variety of novel linkers that allow for the attachment of a broad range of anti-tumor payloads to Fleximer. Once loaded with drug, Fleximer is then attached, through a different highly stable linker, to an antibody or antibody alternative to create a Fleximer-ADC. Mersana’s novel linker systems are designed to be stable in the blood stream and release the potent payloads once inside the targeted cancer cell. Mersana’s Fleximer-ADC technology provides several key advantages over currently available approaches, including: ability to deliver alternative payloads beyond anti-tubulins; opportunity to significantly increase drug loading per antibody; and potential use with antibody fragments and alternative targeting moieties in addition to monoclonal antibodies.
Mersana engineers novel drug conjugates that maximize the potential of new and established therapeutic classes. Mersana is developing, with select pharmaceutical partners, a portfolio of next-generation Fleximer-ADCs with superior properties not found with current ADC technologies. The company is also advancing its own pipeline of Fleximer-ADCs with best-in-class potential to address unmet needs and improve patient outcomes in multiple oncology indications. For more information, please visit www.mersana.com.
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