By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Oncology have been presented. According to news reporting originating in Ankara, Turkey, by NewsRx journalists, research stated, "The voltammetric behavior of anticancer drug irinotecan (IRT) was investigated at poly (methylene blue)/multi-walled carbon nanotube (PMB/MWCNT) modified glassy carbon electrode (GCE). The modified electrode surface was characterized by a scanning electron microscope (SEM)."
The news reporters obtained a quote from the research from Ankara University, "The PMB/MWCNT modified GCE exhibits a distinct shift of the oxidation potential of IRT on the cathodic direction and a considerable enhancement of the peak current compared with bare electrode. The calibration curve was linear between the concentration range 8.0 x 10(-6) and 8.0 x 10(-5) M with the detection limit of 2.14 x 10(-7) M by differential pulse voltammetry in pH 10.0 Britton-Robinson buffer solution. Controlled potential coulometry was applied to find transferred electron numbers due to the oxidation of IRT. In this study, the pK(a) value of IRT was also determined by the dependence of the retention factor on the pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pK(a) at different acetonitrile-water mixtures, ranging between 35 and 50% (v/v) using the reversed-phase liquid chromatography (RP-LC) method with UV detector. IRT was exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the stressed samples were detected by the proposed method."
According to the news reporters, the research concluded: "Sensitive, rapid, and fully validated electrochemical and RP-LC methods for the determination of IRT in its dosage form were presented in details."
For more information on this research see: Analytical application of polymethylene blue-multiwalled carbon nanotubes modified glassy carbon electrode on anticancer drug irinotecan and determination of its ionization constant value. Talanta, 2013;115():911-919. Talanta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Talanta - www.elsevier.com/wps/product/cws_home/525438)
Our news correspondents report that additional information may be obtained by contacting N. Karadas, Ankara University, Fac Med, Dept. of Histol & Embryol, TR-06100 Ankara, Turkey. Additional authors for this research include S. Sanli, B. Akmese, B. Dogan-Topal, A. Can and S.A. Ozkan (see also Oncology).
Keywords for this news article include: Antineoplastics, Ankara, Turkey, Eurasia, Prodrug, Therapy, Oncology, Fullerenes, Irinotecan, Nanotechnology, Carbon Nanotubes, Enzyme Inhibitors, Parasympathomimetic, Emerging Technologies, Radiation-Sensitizing Agents
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