By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on DNA Research are presented in a new report. According to news originating from Aarhus, Denmark, by NewsRx correspondents, research stated, "The Watson-Crick base-pairing with specificity and predictability makes DNA molecules suitable for building versatile nanoscale structures and devices, and the DNA origami method enables researchers to incorporate more complexities into DNA-based devices. Thermally controlled atomic force microscopy in combination with nanomechanical spectroscopy with forces controlled in the pico Newton (pN) range as a novel technique is introduced to directly investigate the kinetics of multistrand DNA hybridization events on DNA origami nanopores under defined isothermal conditions."
Our news journalists obtained a quote from the research from Aarhus University, "For the synthesis of DNA nanostructures under isothermal conditions at 60 degrees C, a higher hybridization rate, fewer defects, and a higher stability are achieved compared to room-temperature studies. By quantifying the assembly times for filling pores in origami structures at several constant temperatures, the fill factors show a consistent exponential increase over time. Furthermore, the local hybridization rate can be accelerated by adding a higher concentration of the staples."
According to the news editors, the research concluded: "The new insight gained on the kinetics of staple-scaffold hybridization on the synthesis of two dimensional DNA origami structures may open up new routes and ideas for designing DNA assembly systems with increased potential for their application."
For more information on this research see: Isothermal Hybridization Kinetics of DNA Assembly of Two-Dimensional DNA Origami. Small, 2013;9(17):2954-2959. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
The news correspondents report that additional information may be obtained from J. Song, Aarhus University, Dept. of Phys & Astron, DK-8000 Aarhus C, Denmark. Additional authors for this research include Z. Zhang, S. Zhang, L. Liu, Q. Li, E.Q. Xie, K.V. Gothelf, F. Besenbacher and M.D. Dong (see also DNA Research).
Keywords for this news article include: Aarhus, Europe, Denmark, DNA Research
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