By a News Reporter-Staff News Editor at Gastroenterology Week -- Research findings on Gastroenterology are discussed in a new report. According to news reporting from Madhya Pradesh, India, by NewsRx journalists, research stated, "The present study discusses lactose-acyclovir-N-succinyl chitosan nanoparticles (Lac-N-Suc-CSNP) using lactose as an asialoglycoprotein receptor (ASGPR) ligand for hepatic parenchymatic cells targeting. For this purpose, N-succinyl chitosan nanoparticles (N-Suc-CSNP) were prepared previously by ionotropic gelation method and lactose was conjugated to the free amino terminal group of chitosan."
The news correspondents obtained a quote from the research from Institute for Pharmaceutical Sciences, "Lactose conjugation with N-Suc-CSNP was confirmed by FT-IR and zeta potential measurements. The Lac-N-Suc-CSNP obtained were characterized for their morphology, particle size, polydispersity index, and zeta potential. The Lac-N-Suc-CSNP showed spherical in shape with 220.3 +/- A 5.0 nm size range, +4.1 +/- A 0.2 mV zeta potential, 62.5 +/- A 1.2 % acyclovir entrapment efficiency and showed 27.3 +/- A 0.9 % cumulative acyclovir release up to 72 h. The acyclovir concentration from Lac-N-Suc-CSNP was found to be 19.9 +/- A 1.62 mu g/g after 24 h administration revealed remarkably targeting potential to the hepatocytes and keep at a high level during the experiment."
According to the news reporters, the research concluded: "These results suggest that Lac-N-Suc-CSNP are potentially vector for hepatocytes targeting."
For more information on this research see: Lactosaminated-N-succinyl chitosan nanoparticles for hepatocyte-targeted delivery of acyclovir. Journal of Nanoparticle Research, 2013;16(1):1-14. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
Our news journalists report that additional information may be obtained by contacting N. Jain, ADINA Inst Pharmaceut Sci, Div Pharmaceut, Opposite JL Nehru Agr Res Center, Sagar 470002, Madhya Pradesh, India. Additional authors for this research include V. Rajoriya, P.K. Jain and A.K. Jain (see also Gastroenterology).
Keywords for this news article include: Asia, India, Hepatocytes, Nanoparticle, Madhya Pradesh, Nanotechnology, Gastroenterology, Emerging Technologies
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