By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Neurodegenerative Diseases. According to news reporting from Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Alzheimer's disease (AD) is a common neurodegenerative disorder with few treatments. The limitations imposed by the blood-brain barrier (BBB) and the non-selective distribution of drugs in the brain have hindered the effective treatment of AD and may result in severe side effects on the normal brains."
The news correspondents obtained a quote from the research from Fudan University, "We developed a dual-functional nanoparticle drug delivery system based on a PEGylated poly (lactic acid) (PLA) polymer. Two targeting peptides that were screened by phage display, TGN and QSH, were conjugated to the surface of the nanoparticles. TGN specifically targets ligands at the BBB, while QSH has good affinity with A beta(1-42), which is the main component of amyloid plaque. Tests probing the bEnd.3 cell uptake and in vivo imaging were conducted to determine the best density of TGN on the nanoparticles' surfaces. The optimal amount of QSH was studied using a Thioflavin T (ThT) binding assay and surface plasmon resonance (SPR) experiments. The optimal maleimide/peptide molar ratio was 3 for both TGN and QSH on the surface of the nanoparticles (T(3)Q(3)-NP), and these nanoparticles achieved enhanced and precise targeted delivery to amyloid plaque in the brains of AD model mice. A MTT assay also validated the safety of this dual-targeted delivery system; little cytotoxicity was demonstrated with both bEnd.3 and PC 12 cells."
According to the news reporters, the research concluded: "The T(3)Q(3)-NP might be a valuable targeting system for AD diagnosis and therapy."
For more information on this research see: Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice. Biomaterials, 2014;35(1):456-465. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting C. Zhang, Fudan University, Minist Educ & PLA, Key Lab Smart Drug Delivery, Shanghai 201203, People's Republic of China. Additional authors for this research include X. Wan, X.Y. Zheng, X.Y. Shao, Q.F. Liu, Q.Z. Zhang and Y. Qian (see also Neurodegenerative Diseases).
Keywords for this news article include: Asia, Amyloid, Shanghai, Dementia, Proteins, Tauopathies, Nanoparticle, Brain Diseases, Nanotechnology, Alzheimer Disease, Emerging Technologies, People's Republic of China, Neurodegenerative Diseases, Central Nervous System Diseases
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