By a News Reporter-Staff News Editor at Biotech Week -- A new study on Stem Cell Research is now available. According to news originating from Hong Kong, People's Republic of China, by NewsRx correspondents, research stated, "Human bone marrow-derived mesenchymal stem cells (MSCs) serve as a reservoir for the continuous renewal of various mesenchymal tissues; however, cellular physiology of ion channels is not fully understood. The present study investigated potential roles of large-conductance Ca(2+) -activated potassium (BKCa ) channels and ether-a-go-go potassium (hEag1 or Kv10.1) channels in regulating cell proliferation and differentiation in human MSCs."
Our news journalists obtained a quote from the research from the University of Hong Kong, "We found that inhibition of BKCa with paxilline or hEag1 with astemizole, or knockdown of BKCa with shRNAs targeting KCa1.1 or hEag1 channels with shRNAs targeting KCNH1 arrested the cells at G0/G1 phase. In addition, silencing BKCa or hEag1 channels significantly reduced adipogenic differentiation with decrease of lipid accumulation and expression of the adipocyte marker PPAR?, and decreased osteogenic differentiation with reduction of mineral precipitation and osteocalcin. These effects were accompanied with a reduced cyclin D1, cyclin E, p-ERK1/2, and p-Akt."
According to the news editors, the research concluded: "Our results demonstrate that BKCa and hEag1 channels not only regulate cell proliferation, but also participate in the adipogenic and osteogenic differentiations in human MSCs, which indicates that BKCa and hEag1 channels may be essential in maintaining bone marrow physiological function and bone regeneration."
For more information on this research see: BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells. Journal of Cellular Physiology, 2014;229(2):202-12. (Wiley-Blackwell - www.wiley.com/; Journal of Cellular Physiology - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4652)
The news correspondents report that additional information may be obtained from Y.Y. Zhang, Dept. of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Taiwan. Additional authors for this research include J. Yue, H. Che, H.Y. Sun, H.F. Tse and G.R Li (see also Stem Cell Research).
Keywords for this news article include: Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Hong Kong, Bone Marrow, Bone Research, Immune System, Bioengineering, Bone Regeneration, Cell Proliferation, Stem Cell Research, Regeneration Medicine, Mesenchymal Stem Cells, People's Republic of China.
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