By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Immunology. According to news reporting originating in Changsha, People's Republic of China, by NewsRx journalists, research stated, "Carcinoembryonic antigen (CEA), which is typically associated with certain tumors and developing fetus, is widely used as a clinical tumor marker for some familiar cancers. In this work, a simple and sensitive electrochemical CEA sensor was developed by employing immunoreaction."
The news reporters obtained a quote from the research from Hunan Normal University, "Gold nanoparticle-decorated graphene composites (Au-GN) were successfully synthesized based on the reduction of HAuCl4 in the presence of graphene. Horseradish peroxidase-labeled anti-CEA antibody (HRP-anti-CEA) and HRP were successively adsorbed on the Au-GN modified glassy carbon electrode. The stepwise assembly process of the immunosensor was characterized by cyclic voltammetry and electrochemical impedance spectroscopy. The introduction of CEA antigens on the electrode surface reduced the electrochemical response of the electron transfer mediator due to the strong steric effect. Under the optimized conditions, the peak current change derived from the differential pulse voltammetry (DPV) measurements (Delta I-DPV) was proportional to the CEA concentration from 0.10 to 80 ng mL(-1) with a detection limit of 0.04 ng mL(-1) (S/N=3). In addition, this new protocol shows good selectivity, stability and reproducibility."
According to the news reporters, the research concluded: "The determination of CEA in human serum samples was performed and received in excellent accordance with the results determined by the enzyme-linked immunosorbent assay (ELISA)."
For more information on this research see: Electrochemical immunoassay for carcinoembryonic antigen using gold nanoparticle-graphene composite modified glassy carbon electrode. Talanta, 2013;116():809-815. Talanta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Talanta - www.elsevier.com/wps/product/cws_home/525438)
Our news correspondents report that additional information may be obtained by contacting L. Zhu, Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ China, Coll Chem & Chem Engn, Changsha 410081, Hunan, People's Republic of China. Additional authors for this research include L.L. Xu, N.M. Jia, B.Z. Huang, L. Tan, S.F. Yang and S.Z. Yao (see also Immunology).
Keywords for this news article include: Asia, Changsha, Chemistry, Immunology, Glycoproteins, Nanotechnology, Electrochemical, Membrane Proteins, Neoplasm Antigens, Gold Nanoparticles, Emerging Technologies, Cell Adhesion Molecules, Biological Tumor Markers, Carcinoembryonic Antigen, People's Republic of China
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