By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Pharmacokinetics. According to news originating from Fort Collins, Colorado, by NewsRx correspondents, research stated, "The absorption, distribution, metabolism and excretion (ADME) and pharmacokinetic (PK) properties of inorganic nanoparticles with hydrodynamic diameters between 2 and 20 nm are presently unpredictable. It is unclear whether unpredictable in vivo properties and effects arise from a subset of molecules in a nanomaterials preparation, or if the ADME/PK properties are ensemble properties of an entire preparation."
Our news journalists obtained a quote from the research from Colorado State University, "Here we characterize the ADME/PK properties of atomically precise preparations of ligand protected gold nanoclusters in a murine model system. We constructed atomistic models and tested in vivo properties for five well defined compounds, based on crystallographically resolved Au25(SR)18 and Au102(SR)44 nanoclusters with different (SR) ligand shells. To rationalize unexpected distribution and excretion properties observed for several clusters in this study and others, we defined a set of atomistic structure-activity relationships (SAR) for nanoparticles, which includes previously investigated parameters such as particle hydrodynamic diameter and net charge, and new parameters such as hydrophobic surface area and surface charge density."
According to the news editors, the research concluded: "Overall we find that small changes in particle formulation can provoke dramatic yet potentially predictable changes in ADME/PK."
For more information on this research see: Structure-activity relationships for biodistribution, pharmacokinetics, and excretion of atomically precise nanoclusters in a murine model. Nanoscale, 2013;5(21):10525-33. (Royal Society of Chemistry - www.rsc.org/; Nanoscale - pubs.rsc.org/en/journals/journalissues/nr)
The news correspondents report that additional information may be obtained from O.A. Wong, Dept. of Chemistry, Colorado State University, Fort Collins, CO 80523, United States. Additional authors for this research include R.J. Hansen, T.W. Ni, C.L. Heinecke, W.S. Compel, D.L. Gustafson and C.J Ackerson (see also Pharmacokinetics).
Keywords for this news article include: Pharmaceuticals, Drugs, Therapy, Colorado, Fort Collins, United States, Pharmacokinetics, North and Central America.
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