By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on Heart Diseases and Conditions. According to news reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Myocardial infarction (MI), and subsequent heart failure, remains a major healthcare problem in the western and developing world and leads to substantial morbidity and mortality. After MI, the ability of the myocardium to recover is closely associated with a complex immune response that often leads to adverse remodeling of the ventricle, and poor prognosis."
Our news editors obtained a quote from the research from King's College, "Currently used clinical imaging modalities allow the assessment of anatomy, perfusion, function, and viability but do not provide insights into specific biological processes. In contrast, novel non-invasive imaging methods, using targeted imaging agents, allow imaging of the molecular processes underlying the post-MI immune cell response, and subsequent remodeling. Therefore, this may have significant diagnostic, prognostic, and therapeutic value, and may help to improve our understanding of post-infarct remodeling, in vivo. Imaging modalities such as magnetic resonance imaging, single-photon emission computed tomography, and positron emission tomography have been used in concert with radiolabelled and (super) paramagnetic probes to image each phase of the immune response. These probes, which target apoptosis, necrosis, neutrophils, monocytes, enzymes, angiogenesis, extracellular matrix, and scar formation have been assessed and validated pre-clinically. Translating this work to the bedside in a cost-effective, clinically beneficial manner remains a significant challenge."
According to the news editors, the research concluded: "This article reviews these new imaging techniques as well as the corresponding pathophysiology."
For more information on this research see: Molecular imaging of myocardial infarction. Basic Research in Cardiology, 2013;109(1):1-16. Basic Research in Cardiology can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Basic Research in Cardiology - www.springerlink.com/content/0300-8428/)
The news editors report that additional information may be obtained by contacting N. Jivraj, Kings Coll London, NIHR Biomed Res Center, London WC2R 2LS, United Kingdom. Additional authors for this research include A. Phinikaridou, A.M. Shah and R.M. Botnar (see also Heart Diseases and Conditions).
Keywords for this news article include: London, Europe, Heart Attack, United Kingdom, Nanotechnology, Molecular Imaging, Vascular Diseases, Myocardial Ischemia, Emerging Technologies, Myocardial Infarction, Heart Diseases and Conditions
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