By a News Reporter-Staff News Editor at Gastroenterology Week -- Fresh data on Gastroenterology are presented in a new report. According to news reporting out of Hangzhou, People's Republic of China, by NewsRx editors, research stated, "The clinical applications of hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) remain to be difficult because the changes of phosphates between normal hepatic tissues and pathological tissues are not so obvious, and furthermore, up to now there is few literature on hepatocyte-targeted 31P MRS. The ATP-loaded Gal-CSO (Gal-CSO/ATP) nanoparticles were prepared and the special cellular uptake of them as evaluated by using HepG-2 tumor cells and A549 tumor cells, respectively."
Our news journalists obtained a quote from the research from Zhejiang University, "Two kinds of cells were incubated with the nanoparticles suspension, respectively. Then were prepared the cell samples and the enhancement efficiency of ATP peaks detected by 31P MRS was evaluated. The cellular uptake rate of Gal-CSO/ATP nanoparticles in HepG-2 cells was higher than that in A549 cells. Furthermore, the enlarged ATP peaks of GalCSO/ATP nanoparticles in HepG-2 cells were higher than those in A549 cells in vitro detected by 31P MRS. GalCSO/ATP nanoparticles have significant targeting efficiency in hepatic cells in vitro and enhancement efficiency of ATP peaks in HepG-2 cells."
According to the news editors, the research concluded: "Furthermore, 31P MRS could be applied in the research of hepatic molecular imaging."
For more information on this research see: Preliminary Study on Hepatocyte-Targeted Phosphorus-31 MRS Using ATP-Loaded Galactosylated Chitosan Oligosaccharide Nanoparticles. Gastroenterology Research and Practice, 2013;():1-6. Gastroenterology Research and Practice can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing - www.hindawi.com; Gastroenterology Research and Practice - www.hindawi.com/journals/grp/)
Our news journalists report that additional information may be obtained by contacting R.S. Yu, Zhejiang University, Coll Pharmaceut Sci, Dept. of Pharmaceut, Hangzhou 310058, Zhejiang, People's Republic of China. Additional authors for this research include X.L. Zhu, J.Z. Sun, D. Shi, Y. Chen, Z.K. Wang, K.Z. Tang and Y.Z. Du (see also Gastroenterology).
Keywords for this news article include: Asia, Hangzhou, Phosphorus, Hepatocytes, Nanoparticle, Nanotechnology, Gastroenterology, Emerging Technologies, People's Republic of China
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