By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Clinical Research have been published. According to news originating from Palermo, Italy, by NewsRx correspondents, research stated, "Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) seem to be involved in the pathophysiology of Behcet's disease, a chronic immune-mediated disease characterized by oral and genital lesions and ocular inflammation."
Our news journalists obtained a quote from the research from the University of Palermo, "Its individual susceptibility seems to be modulated by genetic variants in genes codifying these cytokines. Th1 and Th17 seem to be involved in the disease's active phases, and Th2 seems to affect the development or severity of the disease; however, contrasting data are reported. In this study, some genetic variants of the Th1/Th2 cytokine genes were investigated in Sicilian patients and age-and gender-matched controls. Three very significant associations with Behcet's disease were detected, and combined genotypes associated with increased disease risk were identified."
According to the news editors, the research concluded: "Results obtained point to the key role of Th1/Th2 cytokine genetic variants in disease susceptibility."
For more information on this research see: Pathological implications of Th1/Th2 cytokine genetic variants in Behcet's disease: Data from a pilot study in a Sicilian population. Biochemical Genetics, 2013;51(11-12):967-75. Biochemical Genetics can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Biochemical Genetics - www.springerlink.com/content/0006-2928/)
The news correspondents report that additional information may be obtained from L. Vaccarino, Dept. of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Corso Tukory 211, 90134, Palermo, Italy. Additional authors for this research include G. Triolo, A. Accardo-Palombo, L. Scola, M. Palmeri, M. Bova, G. Candore, D. Lio and C.R Balistreri (see also Clinical Research).
The publisher's contact information for the journal Biochemical Genetics is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Italy, Europe, Palermo, Genetics, Cytokines, Rheumatology, Behcet Disease, Clinical Research, Clinical Trials and Studies, Intercellular Signaling Peptides and Proteins.
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