By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Bone Research have been published. According to news reporting from Genoa, Italy, by NewsRx journalists, research stated, "The present study tested a recently introduced bone substitute material (BSM) with a novel structure to determine its osteoinductive and osteoconductive properties in vitro and in vivo. The specific aims were to determine the microstructure of the as-manufactured BSM, as analyzed with scanning electron microscopy, and to characterize different cellular interactions."
The news correspondents obtained a quote from the research from the University of Genoa, "Human bone marrow stromal cells were cultured in the presence of the BSM. In vitro, attachment of osteoblastlike cells (SAOS-2) to the BSM was observed with the scanning electron microscope. The expression of genes related to osteogenic differentiation (alkaline phosphatase, bone sialoprotein, type I collagen, and osteocalcin) was determined by reverse-transcriptase polymerase chain reaction. In vivo, bone formation was examined with a murine model of ectopic bone formation through histology and computed tomographic scanning by using tissue-engineered constructs with the BSM and ovine bone marrow stromal cells. Early cellular attachment could be detected as early as 6 hours. Cellular morphology developed in the following 66 hours toward a starlike appearance. Human bone marrow stromal cells cultured in the presence of the BSM showed no reduction in their viability. Osteocalcin was up-regulated during cell culturing, demonstrating an osteoinductive effect of BSM. Histologic and computed tomographic analyses showed the formation of new bone surrounding BSM particles, and a vascular meshwork was observed in the porosity of the particles. The analyzed bone substitute of synthetic origin presented osteoinductive properties that may exert a differentiative stimulus upon osteoprogenitor cells."
According to the news reporters, the research concluded: "The tested material allowed cellular adhesion of osteoblastlike cells and, following tissue construct implantation in vivo, supported the formation of new bone."
For more information on this research see: In Vitro and In Vivo Osteoinductive and Osteoconductive Properties of a Synthetic Bone Substitute. International Journal of Oral & Maxillofacial Implants, 2013;28(6):E432-E439. International Journal of Oral & Maxillofacial Implants can be contacted at: Quintessence Publishing Co Inc, 4350 Chandler Drive, Hanover Park, IL 60133, USA (see also Bone Research).
Our news journalists report that additional information may be obtained by contacting E. Conserva, University of Genoa, Dipartimento Oncol Biol & Genet, I-16132 Genoa, Italy. Additional authors for this research include F. Foschi, R. Cancedda and M. Mastrogiacomo.
Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Genoa, Italy, Europe, Bone Marrow, Bone Research, Immune System, Stromal Cells, Bioengineering, Connective Tissue Cells
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