By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Oncology. According to news reporting originating in Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "Nanogold functionalized mesoporous carbon foam (Au/MCF) coupling with a signal amplification by C-Au synergistic silver enhancement was designed for sensitive electrochemical immunosensing of biomarker. The Au/MCF was prepared by in situ growth of nanogold on carboxylated MCF and used as a tracing tag to label signal antibody via the inherent interaction between protein and nanogold."
The news reporters obtained a quote from the research from the Institute of Cancer, "The immunosensor was prepared by covalently immobilizing capture antibody on an electrochemically reduced graphene oxide/chitosan film modified glassy carbon electrode. Through a sandwich-type immunoreaction, Au/MCF tags were captured on the immunoconjugates to induce a silver deposition process. The electrochemical stripping signal of the deposited silver was used to monitor the immunoreaction. The Au/MCF-mediated silver enhancement along with the graphene-promoted electron transfer led to high detection sensitivity of carcinoembryonic antigen. Under optimal conditions, the proposed immunoassay method showed wide linear range from 0.05 pg mL(-1) to 1 ng mL(-1) and a detection limit down to 0.024 pg mL(-1)."
According to the news reporters, the research concluded: "The newly designed amplification strategy holds great potential for ultrasensitive electrochemical biosensing of other analytes."
For more information on this research see: Nanogold/mesoporous carbon foam-mediated silver enhancement for graphene-enhanced electrochemical immunosensing of carcinoembryonic antigen. Biosensors & Bioelectronics, 2014;52():153-158. Biosensors & Bioelectronics can be contacted at: Elsevier Advanced Technology, Oxford Fulfillment Centre The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)
Our news correspondents report that additional information may be obtained by contacting D.J. Lin, Jiangsu Inst Canc Prevent & Cure, Nanjing 210009, Jiangsu, People's Republic of China. Additional authors for this research include J. Wu, H.X. Ju and F. Yan (see also Oncology).
Keywords for this news article include: Asia, Antibodies, Cancer, Jiangsu, Nanogold, Oncology, Chemistry, Immunology, Glycoproteins, Blood Proteins, Nanotechnology, Electrochemical, Immunoglobulins, Membrane Proteins, Neoplasm Antigens, Emerging Technologies, Cell Adhesion Molecules, Biological Tumor Markers, Carcinoembryonic Antigen, People's Republic of China
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