By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Drugs and Therapies have been presented. According to news reporting originating from Evora, Portugal, by NewsRx correspondents, research stated, "The electro-oxidation behavior of five important metabolites of carbamazepine (CBZ) and their potential influence on the voltammetric determination of the parent drug in biological fluids was investigated for the first time. This investigation was performed using cyclic voltammetry, in combination with controlled potential electrolysis and HPLC-DAD-MS analysis of oxidation products of these compounds."
Our news editors obtained a quote from the research from the University of Evora, "Using a sensitive glassy carbon electrode modified with multi-walled carbon nanotubes it was found that each metabolite produces a voltammetric response, that differs from the parent molecule and which can be used in its identification and to gain some insight about the electro-oxidation mechanisms of this class of molecules. Taking into account the HPLC-DAD-MS data, these electro-oxidation mechanisms were advanced and discussed. A voltammetric procedure for the determination of CBZ in human fluids was also been tested. Selecting the most appropriate experimental conditions was verified that the interference of each metabolite and their oxidation products on the voltammetric signal of CBZ may be neglected."
According to the news editors, the research concluded: "The analytical performance of the proposed voltammetric procedure, as well as the correlation of its results with the results obtained from LC-MS, were very good."
For more information on this research see: Electro-oxidation of carbamazepine metabolites: Characterization and influence in the voltammetric determination of the parent drug. Electrochimica Acta, 2013;108():51-65. Electrochimica Acta can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England (see also Drugs and Therapies).
The news editors report that additional information may be obtained by contacting J.G. Teixeira, Univ Evora, HERCULES Lab, P-7000671 Evora, Portugal. Additional authors for this research include A. Veiga, A.J.P. Carvalho and D.M. Teixeira.
Keywords for this news article include: Pharmaceuticals, Evora, Europe, Portugal, Carbamazepine, Drugs and Therapies, Central Nervous System Agents, Dibenzazepine Anticonvulsants
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