By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Stem Cell Research have been presented. According to news reporting out of Baltimore, Maryland, by NewsRx editors, research stated, "Human umbilical cord mesenchymal stem cells (hUCMSCs) are inexhaustible and can be harvested at a low cost without an invasive procedure. However, there has been no report on comparing hUCMSCs with human bone marrow MSCs (hBMSCs) for bone regeneration in vivo."
Our news journalists obtained a quote from the research from the University of Maryland, "The aim of this study was to investigate hUCMSC and hBMSC seeding on macroporous calcium phosphate cement (CPC), and to compare their bone regeneration in critical-sized cranial defects in rats. Cell attachment, osteogenic differentiation and mineral synthesis on RGD-modified macroporous CPC were investigated in vitro. Scaffolds with cells were implanted in 8-mm defects of athymic rats. Bone regeneration was investigated via micro-CT and histological analysis at 4, 12, and 24 weeks. Three groups were tested: CPC with hUCMSCs, CPC with hBMSCs, and CPC control without cells. Percentage of live cells and cell density on CPC in vitro were similarly good for hUCMSCs and hBMSCs. Both cells had high osteogenic expressions of alkaline phosphatase, osteocalcin, collagen I, and Runx2. Bone mineral density and trabecular thickness in hUCMSC and hBMSC groups in vivo were greater than those of CPC control group. New bone amount for hUCMSC-CPC and hBMSC-CPC constructs was increased by 57% and 88%, respectively, while blood vessel density was increased by 15% and 20%, than CPC control group at 24 weeks. hUCMSC-CPC and hBMSC-CPC groups generally had statistically similar bone mineral density, new bone amount and vessel density."
According to the news editors, the research concluded: "HUCMSCs seeded on CPC were shown to match the bone regeneration efficacy of hBMSCs in vivo for the first time. Both hUCMSC-CPC and hBMSC-CPC constructs generated much more new bone and blood vessels than CPC without cells. Macroporous RGD-grafted CPC with stem cell seeding is promising for craniofacial and orthopedic repairs."
For more information on this research see: Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects. Biomaterials, 2013;34(38):9917-9925. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting W.C. Chen, University of Maryland, Sch Med, Marlene & Stewart Greenebaum Canc Center, Baltimore, MD 21201, United States. Additional authors for this research include J. Liu, N. Manuchehrabadi, M.D. Weir, Z.M. Zhu and H.H.K. Xu (see also Stem Cell Research).
Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Anions, Maryland, Baltimore, Bone Marrow, United States, Bone Research, Immune System, Bioengineering, Phosphoric Acids, Bone Regeneration, Calcium Compounds, Calcium Phosphates, Stem Cell Research, Inorganic Chemicals, Phosphorus Compounds, Regeneration Medicine
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