By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Arthritis have been presented. According to news originating from London, United Kingdom, by NewsRx correspondents, research stated, "Osteoarthritis (OA) is a common disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture. Autologous blood-derived products, such as platelet-rich plasma (PRP), are key sources of molecules involved in tissue repair and regeneration."
Our news journalists obtained a quote from the research from Queen Mary University, "These products can deliver a collection of bioactive molecules that have important roles in fundamental processes, including inflammation, angiogenesis, cell migration and metabolism in pathological conditions, such as OA. PRP has anti-inflammatory properties through its effects on the canonical nuclear factor kappa B signalling pathway in multiple cell types including synoviocytes, macrophages and chondrocytes. PRP contains hundreds of different molecules; cells within the joint add to this milieu by secreting additional biologically active molecules in response to PRP. The net results of PRP therapy are varied and can include angiogenesis, the production of local conditions that favour anabolism in the articular cartilage, or the recruitment of repair cells. However, the molecules found in PRP that contribute to angiogenesis and the protection of joint integrity need further clarification."
According to the news editors, the research concluded: "Understanding PRP in molecular terms could help us to exploit its therapeutic potential, and aid the development of novel treatments and tissue-engineering approaches, for the different stages of joint degeneration."
For more information on this research see: Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nature Reviews Rheumatology, 2013;9(12):721-730. Nature Reviews Rheumatology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group - www.nature.com/; Nature Reviews Rheumatology - www.nature.com/nrrheum/)
The news correspondents report that additional information may be obtained from I. Andia, Queen Mary University, Barts & London Sch Med & Dental, Center Sports & Exercise Med, Mile End Hosp, London E1 4DG, United Kingdom (see also Arthritis).
Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Blood, London, Europe, Angiogenesis, Inflammation, United Kingdom, Bioengineering, Joint Diseases, Osteoarthritis, Rheumatic Diseases, Platelet-Rich Plasma, Musculoskeletal Diseases
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