By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Nanowires. According to news reporting originating from Fujian, People's Republic of China, by NewsRx correspondents, research stated, "An amplified colorimetric detection of Hg2+ is proposed by combining T-Hg2+-T base pairs and hybridization chain reaction (HCR). Two hairpins consisting of three-fourths and one-fourth of the horseradish peroxidase (HRP)-mimicking DNAzyme in inactive configuration are used as functional elements."
Our news editors obtained a quote from the research from Fuzhou University, "In the presence of Hg2+, one of the hairpins is opened by an assistant probe with the help of T-Hg2+-T base pairs and this triggers an autonomous cross-opening of the two hairpins using the strand displacement principle, resulting in the formation of DNA nanowires consisting of numerous reunited Q-quadruplex DNAzyme units. The resulting catalytically active hemin/G-quadruplex HRP-mimicking DNAzymes catalyze the oxidation of ABTS2(-) by H2O2 into a green-colored cationic radical ABTS(center dot+) for the colorimetric readout."
According to the news editors, the research concluded: "This 'turn-on' sensing system enables the high sensitive and selective detection of aqueous Hg2+ with a detection limit of 9.7 pM."
For more information on this research see: Amplified colorimetric detection of mercuric ions through autonomous assembly of G-quadruplex DNAzyme nanowires. Biosensors & Bioelectronics, 2014;52():261-264. Biosensors & Bioelectronics can be contacted at: Elsevier Advanced Technology, Oxford Fulfillment Centre The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)
The news editors report that additional information may be obtained by contacting Y.L. Hao, Fuzhou Univ, Dept. of Chem, Fuzhou 350108, Fujian, People's Republic of China. Additional authors for this research include Q.Q. Guo, H.Y. Wu, L.Q. Guo, L.S. Zhong, J. Wang, T.R. Lin, F.F. Fu and G.N. Chen (see also Nanowires).
Keywords for this news article include: Asia, Fujian, Nanotechnology, Emerging Technologies, People's Republic of China
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