By a News Reporter-Staff News Editor at Gastroenterology Week -- Research findings on Health and Medicine are discussed in a new report. According to news originating from Kaohsiung, Taiwan, by NewsRx correspondents, research stated, "In search of a unique and reliable contrast agent targeting pancreatic adenocarcinoma, new multifunctional nanoparticles (MnMEIO-silane-NH2-(MUC4)-mPEG NPs) were successfully developed in this study. Mucin4-expression levels were determined through different imaging studies in a panel of pancreatic tumor cells (HPAC, BxPC-3, and Panc-1) both in vitro and in vivo studies."
Our news journalists obtained a quote from the research from Kaohsiung Medical University, "The in vitro T-2-weighted MR imaging study in HPAC and Panc-1 tumor cells treated with NPs showed -89.1 +/- 5.7% and -0.9 +/- 0.2% contrast enhancement, whereas in in vivo study, it is found to be -81.5 +/- 4.5% versus -19.6 +/- 5.2% (24 h postinjection, 7.0 T), respectively. The T-2-weighted MR and optical imaging studies revealed that the novel agent can specifically and effectively target to mucin4-expressing tumors in nude mice."
According to the news editors, the research concluded: "Hence, it is suggested that MnMEIO-silane-NH2-(MUC4)-mPEG NPs are able to provide an efficient and targeted delivery of MUC4 antibodies to mucin4-expressing pancreatic tumors."
For more information on this research see: Development of a Mucin4-Targeting SPIO Contrast Agent for Effective Detection of Pancreatic Tumor Cells in Vitro and in Vivo. Journal of Medicinal Chemistry, 2013;56(22):9100-9109. Journal of Medicinal Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Medicinal Chemistry - www.pubs.acs.org/journal/jmcmar)
The news correspondents report that additional information may be obtained from S.C. Wu, Kaohsiung Medical University, Dept. of Biomed Sci & Environm Biol, Kaohsiung 807, Taiwan. Additional authors for this research include Y.J. Chen, Y.J. Lin, T.H. Wu and Y.M. Wang (see also Health and Medicine).
Keywords for this news article include: Asia, Taiwan, Pancreas, Kaohsiung, Gastroenterology, Health and Medicine
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