By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Membrane Proteins is the subject of a report. According to news originating from Jefferson, Arkansas, by NewsRx correspondents, research stated, "Silver nanoparticles (AgNPs) are used to manufacture materials with new properties and functions. However, little is known about their toxic or beneficial effects on human health, especially in the respiratory system, where its smooth muscle (ASM) regulates the airway contractility by different mediators, such as acetylcholine (ACh) and nitric oxide (NO)."
Our news journalists obtained a quote from the research from Food and Drug Administration, "The aim of this study was to evaluate the effects of AgNPs on ASM cells. Exposure to AgNPs induced ACh-independent expression of the inducible nitric oxide synthase (iNOS) at 100 mu g/mL, associated with excessive production of NO. AgNPs induced the muscarinic receptor activation, since its blockage with atropine and blockage of its downstream signaling pathway inhibited the NO production. AgNPs at 10 and 100 mu g/mL induced ACh-independent prolonged cytotoxicity and decreased cellular proliferation mediated by the muscarinic receptor-iNOS pathway. However, the concentration of 100 mu g/mL of AgNPs induced muscarinic receptor-independent apoptosis, suggesting the activation of multiple pathways. These data indicate that AgNPs induce prolonged cytotoxic and anti-proliferative effects on ASM cells, suggesting an activation of the muscarinic receptor-iNOS pathway."
According to the news editors, the research concluded: "Further investigation is required to understand the full mechanisms of action of AgNPs on ASM under specific biological conditions."
For more information on this research see: Silver nanoparticles induce anti-proliferative effects on airway smooth muscle cells. Role of nitric oxide and muscarinic receptor signaling pathway. Toxicology Letters, 2014;224(2):246-256. Toxicology Letters can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Toxicology Letters - www.elsevier.com/wps/product/cws_home/505519)
The news correspondents report that additional information may be obtained from M.A. Ramirez-Lee, Food & Drug Administration, Neurochem Lab, Div Neurotoxicol, Natl Center Toxicol Res, Jefferson, AR, United States. Additional authors for this research include H. Rosas-Hernandez, S. Salazar-Garcia, J.M. Gutierrez-Hernandez, R. Espinosa-Tanguma, F.J. Gonzalez, S.F. Ali and C. Gonzalez (see also Membrane Proteins).
Keywords for this news article include: Arkansas, Jefferson, Chemicals, Chemistry, Muscle Cells, Nanoparticle, Nitric Oxide, United States, Nanotechnology, Nitrogen Oxides, Membrane Proteins, Muscarinic Receptors, Cholinergic Receptors, Emerging Technologies, North and Central America, Reactive Nitrogen Species, G-Protein-Coupled Receptors
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