By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from Haifa, Israel, by NewsRx journalists, research stated, "Therapeutic nanotechnologies have made great progress over the past decade. Skepticism has been replaced by the understanding that precision at the nanoscale allows improved treatment modalities in humans."
The news correspondents obtained a quote from the research from the Technion-Israel Institute of Technology, "Principles for designing tumor-targeted drug delivery systems are described. At first, the enhanced permeability and retention (EPR) effect was the major targeting mode, with up to 10% of the injected dose actually reaching tumors. To improve cellular uptake, sugars, antibodies, peptides or other ligands were added to the surface of nanotherapeutics. These can be coupled with external magnetic fields or ultrasonic waves to propel iron oxide or gas-filled particles towards the disease site. Next-generation drug delivery systems will be capable of autonomously swimming towards the disease site and penetrating deep tissue, independent of blood or lymphatic flow. This has been shown to some extent with modified, drug-producing, bacteria."
According to the news reporters, the research concluded: "Interestingly, sperm may be nature's best example of a multifunctional, targeted, high-fidelity, self-propelled, delivery system that we can learn from."
For more information on this research see: The Evolution of Tumor-Targeted Drug Delivery: From the EPR Effect to Nanoswimmers. Israel Journal of Chemistry, 2013;53(9-10):719-727. Israel Journal of Chemistry can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Israel Journal of Chemistry - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1869-5868)
Our news journalists report that additional information may be obtained by contacting N. Zoabi, Technion Israel Inst Technol, Dept. of Chem Engn, Lab Targeted Drug Delivery & Personalized Med Tec, IL-32000 Haifa, Israel. Additional authors for this research include A. Golani-Armon, A. Zinger, M. Reshef, Z. Yaari, D. Vardi-Oknin, Z. Shatsberg, A. Shomar, J. Shainsky-Roitman and A. Schroeder (see also Drugs and Therapies).
Keywords for this news article include: Asia, Haifa, Israel, Therapeutics, Drugs and Therapies, Drug Delivery Systems
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