By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Caco-2 Cells have been published. According to news reporting originating in Wuhan, People's Republic of China, by NewsRx journalists, research stated, "There has been rapid growth in nanotechnology in both the public and private sectors worldwide, but concern about nanosafety exists. To assess size-dependent cytotoxicity on human cancer cells, we studied the cytotoxic effect of three kinds of zinc oxide nanoparticles (ZnO NPs) on human epithelial colorectal adenocarcinoma (Caco-2) cells."
The news reporters obtained a quote from the research from the Hubei University of Technology, "Nanoparticles were first characterized by size, distribution, and intensity. Multiple assays have been adopted to measure the cell activity and oxidative stress. The cytotoxicity of ZnO NPs was time dependent and dose dependent. The 24-h exposure was chosen to confirm the viability and accessibility of the cells and taken as the appropriate time for the following test system. The IC50 value was found at a low concentration. The oxidative stress elicited a significant reduction in glutathione with increase in reactive oxygen species and lactate dehydrogenase. The toxicity resulted in a deletion of cells in the G1 phase and an accumulation of cells in the S and G2/M phases. One type of metallic oxide (ZnO) exerted different cytotoxic effects according to different particle sizes. Data from the previous experiments showed that 26-nm ZnO NPs appeared to have the highest toxicity to Caco-2 cells."
According to the news reporters, the research concluded: "The study demonstrated the toxicity of ZnO NPs to Caco-2 cells and the impact of particle size, which could be useful in the medical applications."
For more information on this research see: In vitro toxicity of different-sized ZnO nanoparticles in Caco-2 cells. Nanoscale Research Letters, 2013;8():1-8. Nanoscale Research Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Nanoscale Research Letters - www.springerlink.com/content/1931-7573/)
Our news correspondents report that additional information may be obtained by contacting T.S. Kang, Hubei University of Technology, Wuhan 430068, People's Republic of China. Additional authors for this research include R.F. Guan, X.Q. Chen, Y.J. Song, H. Jiang and J. Zhao (see also Caco-2 Cells).
Keywords for this news article include: Asia, Wuhan, Zinc Oxide, Caco-2 Cells, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China
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