By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Research findings on Biotechnology are discussed in a new report. According to news originating from Kyoto, Japan, by NewsRx correspondents, research stated, "Aplyronine A (ApA) is a marine natural product that shows potent antitumor activity. While both ApA and ApC, a derivative of ApA that lacks a trimethylserine ester moiety, inhibit actin polymerization in vitro to the same extent, only ApA shows potent cytotoxicity."
Our news journalists obtained a quote from the research from Kyoto University, "Therefore, the molecular targets and mechanisms of action of ApA in cells have remained unclear. We report that ApA inhibits tubulin polymerization in a hitherto unprecedented way. ApA forms a 1:1:1 heterotrimeric complex with actin and tubulin, in association with actin synergistically binding to tubulin, and inhibits tubulin polymerization. Tubulin-targeting agents have been widely used in cancer chemotherapy, but there are no previous descriptions of microtubule inhibitors that also bind to actin and affect microtubule assembly. ApA inhibits spindle formation and mitosis in HeLa S3 cells at 100 pM, a much lower concentration than is needed for the disassembly of the actin cytoskeleton."
According to the news editors, the research concluded: "The results of the present study indicate that ApA represents a rare type of natural product, which binds to two different cytoplasmic proteins to exert highly potent biological activities,."
For more information on this research see: Inhibition of Microtubule Assembly by a Complex of Actin and Antitumor Macrolide Aplyronine A. Journal of the American Chemical Society, 2013;135(48):18089-18095. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)
The news correspondents report that additional information may be obtained from M. Kita, Kyoto University, Inst Chem Res, Uji, Kyoto 6110011, Japan. Additional authors for this research include Y. Hirayama, K. Yoneda, K. Yamagishi, T. Chinen, T. Usui, E. Sumiya, M. Uesugi and H. Kigoshi (see also Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Kyoto, Japan, Drugs, Tubulin, Lactones, Cytoplasm, Macrolides, Chemotherapy, Cytoskeleton, Cellular Structures, Intracellular Space, Microtubule Proteins, Nerve Tissue Proteins
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