By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on Oncology have been published. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "To develop biodegradable docetaxel-loaded self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers were successfully synthesized. These copolymers could form nanoparticles with small size (
The news reporters obtained a quote from the research from Eastern Hepatobiliary Surgical Hospital, "DTX-loaded PLGA(502H)-b-HA(5.6k) nanoparticles (DTX/SANPs) showed a biphasic release pattern within 120 h, and exhibited enhanced cytotoxicity toward CD44-overexpressing MDA-MB-231 cells. Cellular uptake study indicated that PLGA(502H)-b-HA(5.6k) nanoparticles (SANPs) were taken up in MDA-MB-231 cells by CD44-mediated endocytosis. Pharmacokinetics study revealed DTX/SANPs could prolong the circulation of DTX in the blood. In vivo studies demonstrated that SANPs exhibited enhanced tumor targeting and antitumor activity with lower systemic toxicity."
According to the news reporters, the research concluded: "DTX/SANPs have great potential for targeted chemotherapy for CD44-overexpressing breast cancer."
For more information on this research see: Biodegradable self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer. Biomaterials, 2014;35(1):550-566. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting J.B. Huang, Eastern Hepatobiliary Surg Hosp, Dept. of Pharm, Shanghai 200438, People's Republic of China. Additional authors for this research include H. Zhang, Y. Yu, Y. Chen, D. Wang, G.Q. Zhang, G.C. Zhou, J.J. Liu, Z.G. Sun, D.X. Sun, Y. Lu and Y.Q. Zhong (see also Oncology).
Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, Drugs, Shanghai, Oncology, Docetaxel, Chemotherapy, Nanoparticle, Breast Cancer, Nanotechnology, Women's Health, Mitotic Inhibitors, Emerging Technologies, People's Republic of China
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