By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Nanoparticles. According to news reporting originating in Hong Kong, People's Republic of China, by NewsRx journalists, research stated, "Stable and cytocompatible hybrid PEGylated micelles with multimodal imaging capabilities are described. The F3O4-encapsulated polymeric micelles composed of cores containing magnetic nanoparticles and polyethylene glycol (PEG) shells are synthesized by self-assembly of amphiphilic poly(HFMA-co-VBK)-g-PEG copolymers and oleic acid stabilized Fe3O4 nanoparticles."
The news reporters obtained a quote from the research from the University of Hong Kong, "The Fe3O4 magnetic nanoparticles in the core produce T-2-weighted MR imaging functionalities, whereas the small fluorescent monomer carbazole in the polymer shell introduces good fluorescent properties. The multifunctional micelles exhibit excellent paramagnetic properties with the maximum saturation magnetization of 9.61 emu/g and transverse relaxivity rate of 157.44 mM(-1) S-1. In vivo magnetic resonance imaging (MRI) studies reveal enhanced contrast between the liver and spleen. Fluorescence spectra show characteristic emission peaks from carbazole at 350 nm and 365 nm and vivid blue fluorescence can be observed by 2-photon confocal scanning laser microscopy (CLSM)."
According to the news reporters, the research concluded: "In vivo optical imaging demonstrates the unique fluorescent characteristics of the Fe3O4-encapsulated polymeric micelles in the liver and spleen and the excellent multifunctional properties suggest potential clinical use as nanocarriers in magnetic resonance imaging and optical imaging."
For more information on this research see: Self-assembled magnetic fluorescent polymeric micelles for magnetic resonance and optical imaging. Biomaterials, 2014;35(1):344-355. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting K. Yan, University of Hong Kong, Dept. of Orthopaed & Traumatol, Hong Kong, Hong Kong, People's Republic of China. Additional authors for this research include H. Li, P.H. Li, H. Zhu, J. Shen, C.F. Yi, S.L. Wu, K.W.K. Yeung, Z.S. Xu, H.B. Xu and P.K. Chu (see also Nanoparticles).
Keywords for this news article include: Asia, Hong Kong, Nanotechnology, Emerging Technologies, Magnetic Nanoparticles, People's Republic of China
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC