By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Sulfur Amino Acids have been published. According to news originating from Halle, Germany, by NewsRx correspondents, research stated, "Poly(ethylene glycol) (PEG) is often used to biocompatibilize surfaces of implantable biomedical devices. Here, block copolymers consisting of PEG and l-cysteine-containing poly(amino acid)s (PAA's) were synthesized as polymeric multianchor systems for the covalent attachment to gold surfaces or surfaces decorated with gold nanoparticles."
Our news journalists obtained a quote from the research from the University of Halle-Wittenberg, "Amino-terminated PEG was used as macroinitiator in the ring-opening polymerization, (ROP), of respective amino acid N-carboxyanhydrides (NCA's) of l-cysteine (l-Cys), l-glutamate (l-Glu), and l-lysine (l-Lys). The resulting block copolymers formed either diblock copolymers, PEG-b-p(l-Glu(x)-co-l-Cys(y)) or triblock copolymers, PEG-b-p(l-Glu)(x)-b-p(l-Cys)(y). The monomer feed ratio matches the actual copolymer composition, which, together with high yields and a low polydispersity, indicates that the NCA ROP follows a living mechanism. The l-Cys repeat units act as anchors to the gold surface or the gold nanoparticles and the l-Glu repeat units act as spacers for the reactive l-Cys units. Surface analysis by atomic force microscopy revealed that all block copolymers formed homogenous and pin-hole free surface coatings and the phase separation of mutually immiscible PEG and PAA blocks was observed."
According to the news editors, the research concluded: "A different concept for the biocompatibilization of surfaces was followed when thiol-terminated p(l-Lys) homopolymer was first grafted to the surface and then covalently decorated with HOOC-CH2-PEG-b-p(Bz-l-Glu) polymeric micelles."
For more information on this research see: The Behavior of Poly(amino acids) Containing L-Cysteine and Their Block Copolymers with Poly(ethylene glycol) on Gold Surfaces. Journal of Polymer Science Part A-Polymer Chemistry, 2014;52(2):248-257. Journal of Polymer Science Part A-Polymer Chemistry can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA (see also Sulfur Amino Acids).
The news correspondents report that additional information may be obtained from R. Obeid, University of Halle Wittenberg, Dept. of Chem, D-06099 Halle, Saale, Germany. Additional authors for this research include T. Armstrong, X.J. Peng, K. Busse, J. Kressler and C. Scholz.
Keywords for this news article include: Halle, Europe, Germany, Alkenes, Cysteine, Peptides, Proteins, Nanotechnology, Ethylene Glycols, Gold Nanoparticles, Sulfur Amino Acids, Neutral Amino Acids, Sulfhydryl Compounds, Emerging Technologies
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