The news reporters obtained a quote from the research, "Importantly, the study indicates that vitamin B-12-conjugated nanoparticles circumnavigate the lysosomal compartment, the destination of soluble vitamin B-12 ligand. Whereas cellular trafficking of soluble B-12 is confirmed to occur via the clathrin-mediated pathway, transport of B-12-conjugated nanoparticles appears to predominantly take place by a route that is perturbed by caveolae-specific inhibitors."
According to the news reporters, the research concluded: "This data suggests that, following its conjugation to nanoparticles, in addition to dramatically increasing the cellular uptake of nanoparticles, the normal cell trafficking of B-12 is switched to an alternative pathway, omitting the lysosomal stage: a result with important implications for oral delivery of nanoparticulate diagnostics and therapeutics."
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