By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Epithelial Cells have been published. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Urethral defects are common and frequent disorders and are difficult to treat. Simple natural or synthetic materials do not provide a satisfactory curative solution for long urethral defects, and urethroplasty with large areas of autologous tissues is limited and might interfere with wound healing."
The news reporters obtained a quote from the research from the Shanghai Key Laboratory of Tissue Engineering, "In this study, adipose-derived stem cells were used. These cells can be derived from a wide range of sources, have extensive expansion capability, and were combined with oral mucosal epithelial cells to solve the problem of finding seeding cell sources for producing the tissue-engineered urethras. We also used the synthetic biodegradable polymer poly-glycolic acid (PGA) as a scaffold material to overcome issues such as potential pathogen infections derived from natural materials (such as de-vascular stents or animal-derived collagen) and differing diameters. Furthermore, we used a bioreactor to construct a tissue-engineered epithelial-muscular lumen with a double-layer structure (the epithelial lining and the muscle layer). Through these steps, we used an epithelial-muscular lumen built in vitro to repair defects in a canine urethral defect model (1 cm). Canine urethral reconstruction was successfully achieved based on image analysis and histological techniques at different time points."
According to the news reporters, the research concluded: "This study provides a basis for the clinical application of tissue engineering of an epithelial-muscular lumen."
For more information on this research see: The effect of mechanical extension stimulation combined with epithelial cell sorting on outcomes of implanted tissue-engineered muscular urethras. Biomaterials, 2014;35(1):105-112. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting Q. Fu, Shanghai Key Lab Tissue Engn, Shanghai 200011, People's Republic of China. Additional authors for this research include C.L. Deng, R.Y. Zhao, Y. Wang and Y.L. Cao (see also Epithelial Cells).
Keywords for this news article include: Asia, Shanghai, Engineering, Epithelial Cells, People's Republic of China
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