By a News Reporter-Staff News Editor at Biotech Week -- A new study on Oncology is now available. According to news originating from Wuhan, People's Republic of China, by NewsRx correspondents, research stated, "A 'turn off-on' mode has been established by using the interaction between platinum anticancer drugs and DNA as input signal and the fluorescence reversible change of quantum dots (QDs) as output signal. The QDs fluorescence can be quenched by platinum anticancer drugs via photo-induced electron transfer process, rendering the system into 'turn off' status, and the system can then be 'turned on' when fluorescence is restored due to covalent conjugation between DNA and platinum anticancer drugs."
Our news journalists obtained a quote from the research from Wuhan University, "This dual-directional fluorescence change realized the detection of cisplatin and DNA, overcoming the selectivity problem commonly existed in the traditional mono-directional fluorescence detection mode. The reversible fluorescent 'turn off-on' mode has been further employed to study the interactions between DNA and different platinum anticancer drugs (cisplatin, oxaliplatin and carboplatin). Furthermore, the impacts of different types of DNAs (different in base sequence, chain length and ssDNA/dsDNA) on the mode are also explored."
According to the news editors, the research concluded: "This simple, fast and convenient spectroscopic method owns promising applications in the study on interaction between medical molecules and DNA, and in biochemical detections."
For more information on this research see: "Turn off-on" fluorescent sensor for platinum drugs-DNA interactions based on quantum dots. Biosensors & Bioelectronics, 2014;52():29-35. Biosensors & Bioelectronics can be contacted at: Elsevier Advanced Technology, Oxford Fulfillment Centre The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)
The news correspondents report that additional information may be obtained from D. Zhao, Wuhan University, Coll Chem & Mol Sci, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, People's Republic of China. Additional authors for this research include J.T. Li, T.M. Yang and Z.K. He (see also Oncology).
Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, Wuhan, Drugs, Therapy, Oncology, Cisplatin, DNA Research, Quantum Dots, Nanotechnology, Quantum Physics, Alkylating Agents, Emerging Technologies, People's Republic of China
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