By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Nanotechnology and Microtechnology are discussed in a new report. According to news originating from Changsha, People's Republic of China, by NewsRx correspondents, research stated, "In this work, a DNA inter-strand replacement strategy for therapeutic activity is successfully designed for multimodal therapy. In this multimodal therapy, chlorin e6 (Ce6) photosensitizer molecules are used for photodynamic therapy (PDT), while aptamer-AuNRs, are used for selective binding to target cancer cells and for photothermal therapy (PTT) with near infrared laser irradiation."
Our news journalists obtained a quote from the research from Hunan University, "Aptamer Sgc8, which specifically targets leukemia T cells, is conjugated to an AuNR by a thiol-Au covalent bond and then hybridized with a Ce6-labeled photosensitizer/reporter to form a DNA double helix. When target cancer cells are absent, Ce6 is quenched and shows no PDT effect. However, when target cancer cells are present, the aptamer changes structure to release Ce6 to produce singlet oxygen for PDT upon light irradiation."
According to the news editors, the research concluded: "Importantly, by combining photosensitizer and photothermal agents, PTT/PDT dual therapy supplies a more effective therapeutic outcome than either therapeutic modality alone."
For more information on this research see: Photosensitizer-Gold Nanorod Composite for Targeted Multimodal Therapy. Small, 2013;9(21):3678-3684. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
The news correspondents report that additional information may be obtained from J. Wang, Hunan Univ, Coll Chem & Chem Engn, Collaborat Innovat Center Chem & Mol Med, Changsha 410082, People's Republic of China. Additional authors for this research include M.X. You, G.Z. Zhu, M.I. Shukoor, Z. Chen, Z.L. Zhao, M.B. Altman, Q. Yuan, Z. Zhu, Y. Chen, C.Z. Huang and W.H. Tan (see also Nanotechnology and Microtechnology).
Keywords for this news article include: Asia, Cancer, Therapy, Changsha, Oncology, People's Republic of China, Nanotechnology and Microtechnology
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