By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news reporting originating in Afyon, Turkey, by NewsRx journalists, research stated, "One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells, which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention."
The news reporters obtained a quote from the research from the University of Afyon Kocatepe, "Nanoscale-based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an external magnetic field. Thus, the drug can be carried to the targeted site safely. The aim of this study is to prepare poly(dl-lactic-co-glycolic acid) (PLGA)-coated magnetic nanoparticles and load anti-cancer drug, doxorubicin to them. For this purpose, magnetite (Fe3O4) iron oxide nanoparticles were synthesized as a magnetic core material (MNP) and then coated with oleic acid. Oleic acid-coated MNP (OA-MNP) was encapsulated into PLGA. Effects of different OA-MNP/PLGA ratios on magnetite entrapment efficiency were investigated. Doxorubicin-loaded magnetic polymeric nanoparticles (DOX-PLGA-MNP) were prepared. After the characterization of prepared nanoparticles, their cytotoxic effects on MCF-7 cell line were studied. PLGA-coated magnetic nanoparticles (PLGA-MNP) had a proper size and superparamagnetic character. The highest magnetite entrapment efficiency of PLGA-MNP was estimated as 63 % at 1:8 ratio. Cytotoxicity studies of PLGA-MNP did not indicate any notable cell death between the concentration ranges of 2 and 125 mu g/ml. Drug loading efficiency was estimated as 32 %, and it was observed that DOX-PLGA-MNP showed significant cytotoxicity on MCF-7 cells compared to PLGA-MNP. The results showed that prepared nanoparticles have desired size and superparamagnetic characteristics without serious toxic effects on cells."
According to the news reporters, the research concluded: "These nanoparticles may be suitable for targeted drug delivery applications."
For more information on this research see: Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery. Journal of Nanoparticle Research, 2013;16(1):1-13. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
Our news correspondents report that additional information may be obtained by contacting G. Tansik, Afyon Kocatepe Univ, Dept. of Chem Engn, TR-03200 Afyon, Turkey. Additional authors for this research include A. Yakar and U. Gunduz (see also Drugs and Therapies).
Keywords for this news article include: Antibiotics - Antineoplastics, Pharmaceuticals, Afyon, Turkey, Cancer, Eurasia, Oncology, Chemotherapy, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, Magnetic Nanoparticles, Doxorubicin Hydrochloride
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