By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Myeloid Cells are presented in a new report. According to news reporting out of Fukuoka, Japan, by NewsRx editors, research stated, "Total joint replacement (TJR) is a common and effective surgical procedure for hip or knee joint reconstruction. However, the production of wear particles is inevitable for all TJRs, which activates macrophages and initiates an inflammatory cascade often resulting in bone loss, prosthetic loosening and eventual TJR failure."
Our news journalists obtained a quote from the research from Kyushu University, "Macrophage Chemoattractant Protein-1 (MCP-1) is one of the most potent cytokines responsible for macrophage cell recruitment, and previous studies suggest that mutant MCP-1 proteins such as 7ND may be used as a decoy drug to block the receptor and reduce inflammatory cell recruitment. Here we report the development of a biodegradable, layer-by-layer (LBL) coating platform that allows efficient loading and controlled release of 7ND proteins from the surface of orthopedic implants using as few as 14 layers. Scanning electron microscopy and fluorescence imaging confirmed effective coating using the LBL procedure on titanium rods. 7ND protein loading concentration and release kinetics can be modulated by varying the polyelectrolytes of choice, the polymer chemistry, the pH of the polyelectrolyte solution, and the degradation rate of the LBL assembly. The released 7ND from LBL coating retained its bioactivity and effectively reduced macrophage migration towards MCP-1. Finally, the LBL coating remained intact following a femoral rod implantation procedure as determined by immunostaining of the 7ND coating."
According to the news editors, the research concluded: "The LBL platform reported herein may be applied for in situ controlled release of 7ND protein from orthopedic implants, to reduce wear particle-induced inflammatory responses in an effort to prolong the lifetime of implants."
For more information on this research see: Mutant MCP-1 protein delivery from layer-by-layer coatings on orthopedic implants to modulate inflammatory response. Biomaterials, 2013;34(38):10287-10295. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting M. Keeney, Kyushu University, Dept. of Cardiovasc Res Dev & Translat Med, Fukuoka 812, Japan. Additional authors for this research include H. Waters, K. Barcay, X.Y. Jiang, Z.Y. Yao, J. Pajarinen, K. Egashira, S.B. Goodman and F. Yang (see also Myeloid Cells).
Keywords for this news article include: Asia, Japan, Fukuoka, Immunology, Macrophages, Myeloid Cells, Connective Tissue Cells, Mononuclear Phagocyte System
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