By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Bone Research have been published. According to news reporting from Atlanta, Georgia, by NewsRx journalists, research stated, "Endogenous signals originating at the site of injury are involved in the paracrine recruitment, proliferation, and differentiation of circulating progenitor and diverse inflammatory cell types. Here, we investigate a strategy to exploit endogenous cell recruitment mechanisms to regenerate injured bone by local targeting and activation of sphingosine-1 -phosphate (SIP) receptors."
The news correspondents obtained a quote from the research from the Georgia Institute of Technology, "A mandibular defect model was selected for evaluating regeneration of bone following trauma or congenital disease. The particular challenges of mandibular reconstruction are inherent in the complex anatomy and function of the bone given that the area is highly vascularized and in close proximity to muscle. Nanofibers composed of poly(DL-lactide-co-glycolide) (PLAGA) and polycaprolactone (PCL) were used to delivery FTY720, a targeted agonist of SIP receptors 1 and 3. In vitro culture of bone progenitor cells on drug-loaded constructs significantly enhanced SDF1 alpha mediated chemotaxis of bone marrow mononuclear cells. In vivo results show that local delivery of FTY720 from composite nanofibers enhanced blood vessel ingrowth and increased recruitment of M2 alternatively activated macrophages, leading to significant osseous tissue ingrowth into critical sized defects after 12 weeks of treatment. These results demonstrate that local activation of S1P receptors is a regenerative cue resulting in recruitment of wound healing or anti-inflammatory macrophages and bone healing."
According to the news reporters, the research concluded: "Use of such small molecule therapy can provide an alternative to biological factors for the clinical treatment of critical size craniofacial defects."
For more information on this research see: The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. Biomaterials, 2013;34(38):9853-9862. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting A. Das, Georgia Inst Technol, Atlanta, GA 30332, United States. Additional authors for this research include C.E. Segar, B.B. Hughley, D.T. Bowers and E.A. Botchwey (see also Bone Research).
Keywords for this news article include: Atlanta, Georgia, Nanofiber, Treatment, Immunology, Macrophages, United States, Bone Research, Myeloid Cells, Nanotechnology, Emerging Technologies, Connective Tissue Cells, North and Central America, Mononuclear Phagocyte System
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