By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Biomedicine and Biomedical Engineering have been presented. According to news reporting out of Southampton, United Kingdom, by NewsRx editors, research stated, "Skeletal stem cells (SSCs) and impaction bone grafting (IBG) can be combined to produce a mechanically stable living bone composite. This novel strategy has been translated to the treatment of avascular necrosis of the femoral head."
Our news journalists obtained a quote from the research from the University of Southampton, "Surgical technique, clinical follow-up and retrieval analysis data of this translational case series is presented. SSCs and milled allograft were impacted into necrotic bone in five femoral heads of four patients. Cell viability was confirmed by parallel in vitro culture of the cell-graft constructs. Patient follow-up was by serial clinical and radiological examination. Tissue engineered bone was retrieved from two retrieved femoral heads and was analysed by histology, microcomputed tomography (mu CT) and mechanical testing. Three patients remain asymptomatic at 22- to 44-month follow-up. One patient (both hips) required total hip replacement due to widespread residual necrosis. Retrieved tissue engineered bone demonstrated a mature trabecular micro-architecture histologically and on mu CT. Bone density and axial compression strength were comparable to trabecular bone. Clinical follow-up shows this to be an effective new treatment for focal early stage avascular necrosis of the femoral head."
According to the news editors, the research concluded: "Unique retrieval analysis of clinically translated tissue engineered bone has demonstrated regeneration of tissue that is both structurally and functionally analogous to normal trabecular bone."
For more information on this research see: A tissue engineering strategy for the treatment of avascular necrosis of the femoral head. Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 2013;11(6):319-325. Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland can be contacted at: Royal College Surgeons Edinburgh, Nicolson St, Edinburgh EH8 9DW, Scotland (see also Biomedicine and Biomedical Engineering).
Our news journalists report that additional information may be obtained by contacting A. Aarvold, University of Southampton, Inst Dev Sci, Center Human Dev Stem Cells & Regenerat, Bone & Joint Res Grp, Southampton SO16 6YD, Hants, United Kingdom. Additional authors for this research include J.O. Smith, E.R. Tayton, A.M.H. Jones, J.I. Dawson, S. Lanham, A. Briscoe, D.G. Dunlop and R.O.C. Oreffo.
Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, Europe, Treatment, Southampton, Bone Research, United Kingdom, Bioengineering
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