By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Health and Medicine is now available. According to news originating from Urbana, Illinois, by NewsRx correspondents, research stated, "The single photon emission microscope (SPEM) is an instrument developed to obtain high spatial resolution single photon emission computed tomography (SPECT) images of small structures inside the mouse brain. SPEM consists of two independent imaging devices, which combine a multipinhole collimator, a high-resolution, thallium-doped cesium iodide [CsI(Tl)] columnar scintillator, a demagnifying/intensifier tube, and an electron-multiplying charge-coupling device (CCD)."
Our news journalists obtained a quote from the research from the University of Illinois, "Collimators have 300- and 450-mm diameter pinholes on tungsten slabs, in hexagonal arrays of 19 and 7 holes. Projection data are acquired in a photon-counting strategy, where CCD frames are stored at 50 frames per second, with a radius of rotation of 35 mm and magnification factor of one. The image reconstruction software tool is based on the maximum likelihood algorithm. Our aim was to evaluate the spatial resolution and sensitivity attainable with the seven-pinhole imaging device, together with the linearity for quantification on the tomographic images, and to test the instrument in obtaining tomographic images of different mouse organs. A spatial resolution better than 500 mm and a sensitivity of 21.6 counts?.s(-1).MBq(-1) were reached, as well as a correlation coefficient between activity and intensity better than 0.99, when imaging Tc-99m sources. Images of the thyroid, heart, lungs, and bones of mice were registered using Tc-99m-labeled radiopharmaceuticals in times appropriate for routine preclinical experimentation of
According to the news editors, the research concluded: "We plan to extend the instrument's field of view to fix larger animals and to combine data from both detectors to reduce the acquisition time or applied activity."
For more information on this research see: Performance assessment of the single photon emission microscope: high spatial resolution SPECT imaging of small animal organs. Brazilian Journal of Medical and Biological Research, 2013;46(11):936-942. Brazilian Journal of Medical and Biological Research can be contacted at: Assoc Bras Divulg Cientifica, Faculdade Medicina, Sala 21, 14049 Ribeirao Preto, Sao Paulo, 00, Brazil (see also Health and Medicine).
The news correspondents report that additional information may be obtained from J. Mejia, University of Illinois, Dept. of Nucl Plasma & Radiol Engn, Urbana, IL 61801, United States. Additional authors for this research include M.A. Reis, A.C.C. Miranda, I.R. Batista, M.R.F. Barboza, M.C. Shih, G. Fu, C.T. Chen, L.J. Meng, R.A. Bressan and E. Amaro.
Keywords for this news article include: Urbana, Illinois, United States, Health and Medicine, North and Central America
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