By a News Reporter-Staff News Editor at Women's Health Weekly -- A new study on Oncology is now available. According to news reporting from Montreal, Canada, by NewsRx journalists, research stated, "Carbon nanotube (CNT) possesses excellent properties as a drug carrier. To overcome the challenge of drug functionalization with CNT, we have developed a lipid-drug approach for efficient drug loading onto CNT, in which a long chain lipid molecule is conjugated to the drug molecule so that the lipid-drug can be loaded directly onto CNT through binding of the lipid 'tail' in the drug molecule to CNT surfaces via hydrophobic interactions."
The news correspondents obtained a quote from the research from McGill University, "In a proof-of-concept study, drug paclitaxel (PTX) was conjugated with a nontoxic lipid molecule docosanol for functionalization with CNT. Folic acid was also conjugated to CNT for targeted drug delivery. High level of drug loading onto SWNT could be achieved by lipid-drug approach. Conjugation of FA to SWNT-lipid-PTX led to an increase in cell penetration capacity, and the targeted SWNT-lipid-PTX showed much improved drug efficacy in vitro in comparison to free drug Taxol and non-targeted SWNT-lipid-PTX at 48 h (78.5% vs. 31.6% and 59.1% in cytotoxicity respectively, p< 0.01). In vivo analysis using a human breast cancer xenograft mice model also confirmed the improved drug efficacy."
According to the news reporters, the research concluded: "The targeted SWNT-lipid-PTX was found non-toxic as evaluated by biochemical analysis using blood samples, and by histological analysis of major organs."
For more information on this research see: Carbon nanotube lipid drug approach for targeted delivery of a chemotherapy drug in a human breast cancer xenograft animal model. Biomaterials, 2013;34(38):10109-10119. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting W. Shao, McGill University, Dept. of Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada. Additional authors for this research include A. Paul, B. Zhao, C. Lee, L. Rodes and S. Prakash (see also Oncology).
Keywords for this news article include: Drugs, Quebec, Canada, Montreal, Oncology, Xenograft, Fullerenes, Chemotherapy, Breast Cancer, Women's Health, Carbon Nanotubes, Xenotransplantion, North and Central America
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