By a News Reporter-Staff News Editor at Gastroenterology Week -- New research on Acute Pancreatitis is the subject of a report. According to news reporting from Guangdong, People's Republic of China, by NewsRx journalists, research stated, "Currently, available methods for diagnosis of acute pancreatitis (AP) are mainly dependent on serum enzyme analysis and imaging techniques that are too low in sensitivity and specificity to accurately and promptly diagnose AR The lack of early diagnostic tools highlights the need to search for a highly effective and specific diagnostic method. In this study, we synthesized a conditionally activated, gadolinium-containing, nanoparticle-based MRI nanoprobe as a diagnostic tool for the early identification of AR Gadolinium diethylenetriaminepentaacetic fatty acid (Gd-DTPA-FA) nanoparticles were synthesized by conjugation of DTPA-FA ligand and gadolinium acetate."
The news correspondents obtained a quote from the research from Sun Yat-Sen University, "Gd-DTPA-FA exhibited low cytotoxicity and excellent biocompatibility when characterized in vitro and in vivo studies. L-arginine induced a gradual increase in the intensity of the T1-weighted MRI signal from 1 h to 36 h in AP rat models."
According to the news reporters, the research concluded: "The increase in signal intensity was most significant at 1 h, 6 h and 12 h."
For more information on this research see: Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis. Biomaterials, 2014;35(1):356-367. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting H.W. Zhang, Sun Yat Sen UniversitySch Chem & Chem Engn, Guangzhou 510275, Guangdong, People's Republic of China. Additional authors for this research include L.Q. Wang, Q.F. Xiang, Q. Zhong, L.M. Chen, C.X. Xu, X.H. Xiang, B. Xu, F. Meng, Y.Q. Wan and D.Y.B. Deng (see also Acute Pancreatitis).
Keywords for this news article include: Asia, Lipase, Guangdong, Gadolinium, Nanoparticle, Nanotechnology, Gastroenterology, Acute Pancreatitis, Pancreatic Diseases, Emerging Technologies, Enzymes and Coenzymes, Digestive System Diseases, People's Republic of China, Lanthanoid Series Elements
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