By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Melanomas have been published. According to news reporting originating from Moscow, Russia, by NewsRx correspondents, research stated, "Targeted sodium-iodide symporter (NIS) gene transfer can be considered as a promising approach for diagnostics of specific types of cancer. For this purpose we used targeted polyplexes based on PEI-PEG -MC1SP block-copolymer containing MC1SP-peptide, a ligand specific for melanocortin receptor-1 (MC1R) overexpressed on melanoma cells."
Our news editors obtained a quote from the research from Lomonosov Moscow State University, "Targeted polyplexes demonstrated enhanced NIS gene transfer compared to non-targeted (lacking MC1SP) ones in vitro. Using dorsal skinfold chamber and intravital microscopy we evaluated accumulation and microdistribution of quantum dot-labeled polyplexes in tumor and normal subcutaneous tissues up to 4 h after intravenous injection. Polyplexes demonstrated significantly higher total accumulation in tumor tissue in comparison with subcutaneous ones (control). Targeted and non-targeted polyplexes extravasated and penetrated into the tumor tissue up to 20 gm from the vessel walls. In contrast, in normal subcutaneous tissue polyplexes penetrated not more than 3 p.m from the vessel walls with the level of extravasated polyplexes 400-fold less than in tumor. Accumulated polyplexes in tumor tissue caused NIS gene expression."
According to the news editors, the research concluded: "Subsequent I-123(-) intravenous injection resulted in 6.8 +/- 1.1 and 4.5 +/- 0.8% ID/g (p < 0.001) iodide accumulation in tumors in the case of targeted and non-targeted polyplexes, respectively, as was shown using SPECT/CT."
For more information on this research see: Microdistribution of MC1R-targeted polyplexes in murine melanoma tumor tissue. Biomaterials, 2013;34(38):10209-10216. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news editors report that additional information may be obtained by contacting M.O. Durymanov, Lomonosov Moscow State University, Fac Biol, Dept. of Physicochem Biol, Moscow 119991, Russia. Additional authors for this research include T.A. Slastnikova, A.I. Kuzmich, Y.V. Khramtsov, A.V. Ulasov, A.A. Rosenkranz, S.Y. Egorov, E.D. Sverdlov and A.S. Sobolev (see also Melanomas).
Keywords for this news article include: Moscow, Russia, Eurasia, Melanomas
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