By a News Reporter-Staff News Editor at Anti-Infectives Week -- Fresh data on Interface Science are presented in a new report. According to news reporting from Provo, Utah, by NewsRx journalists, research stated, "New synthesis techniques are providing increasing control over many inorganic nanoparticle characteristics, facilitating the creation of new multifunctional theranostics. This report proposes the synthesis and testing of a combination nanoparticle comprised of a maghemite core for enhanced T2 MRI contrast diagnostics, a colloidal silver shell acting as an antimicrobial and therapeutic vehicle, and a ceragenin (CSA-124) surfactant providing microbial adhesion."
The news correspondents obtained a quote from the research from Brigham Young University, "A polyacrylic acid functionalized maghemite nanoparticle is synthesized by a high temperature organic phase reduction followed by thiol functionalization and gold cluster seeding. A silver shell is formed through AgNO3 reduction, and an oriented monolayer of the thiolated ceragenin, is bound through a self-assembly process. The process and products are characterized throughout synthesis through TEM, DLS, FT-IR, UV-Vis, ICP-OES, HPLC-ESI-TOF-MS, DC magnetization and susceptibility, X-ray diffraction, and in vitro MRI. Synthesized Diagnostic Antimicrobial Nanoparticles (DANs) were found to have a spherical morphology with a diameter of 32.47 +/- 1.83 nm, hydrodynamic diameter of 53.05 +/- 1.20 nm, maximum magnetic moment of 12 emu/g NP (54 emu/g Fe) with little variation due to temperature, and are predominantly paramagnetic. In vitro MRI studies show that DANs contrast well at concentrations as low as 9 ppm, and successfully adhere to Staphylococcus aureus."
According to the news reporters, the research concluded: "DAN MIC was determined to be approximately 12 ppm and 24 ppm against S. aureus and Escherichia coil respectively."
For more information on this research see: Maghemite, silver, ceragenin conjugate particles for selective binding and contrast of bacteria. Journal of Colloid and Interface Science, 2014;413():167-174. Journal of Colloid and Interface Science can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Journal of Colloid and Interface Science - www.elsevier.com/wps/product/cws_home/622861)
Our news journalists report that additional information may be obtained by contacting M.A. Hoppens, Brigham Young University, Dept. of Chem & Biochem, Provo, UT 84602, United States. Additional authors for this research include Z.E.W. Wheeler, A.T. Qureshi, K. Hogan, A. Wright, G.G. Stanley, D. Young, P. Savage and D. Hayes (see also Interface Science).
Keywords for this news article include: Utah, Antimicrobials, Provo, Therapy, United States, Interface Science, North and Central America
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