By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Biotechnology is the subject of a report. According to news reporting out of Cape Town, South Africa, by NewsRx editors, research stated, "The highly pathogenic avian influenza virus H5N1 is a potent pandemic threat because of its frequent transmission from birds to humans and the increasing possibility of human to human transmission. During the 2009 H1N1 pandemic it was clear that rapid influenza vaccine production is a problem worldwide."
Our news journalists obtained a quote from the research from the University of Cape Town, "Additionally, developing countries like South Africa generally cannot produce their own influenza vaccines because the traditional egg-based vaccine production method currently employed is too lengthy and too difficult to establish. As part of an exercise aimed at exploring the feasibility of producing emergency response influenza vaccines, we investigated an experimental DNA vaccine to the H5N1 influenza virus. We focused on the virion haemagglutinin, because it elicits the primary neutralising immune response following infection. Accordingly, we developed an H5N1 DNA vaccine with full-length and truncated versions of the haemagglutinin gene, to match previously developed protein candidates. Vaccinated mice developed a strong antibody response to the haemagglutinin protein."
According to the news editors, the research concluded: "In addition, the full-length H5 gene elicited high haemagglutination inhibition titres in mice, indicating that it has potential as a candidate pandemic vaccine for South Africa."
For more information on this research see: An H5N1 influenza DNA vaccine for South Africa. South African Journal of Science, 2013;109(9-10):97-100. South African Journal of Science can be contacted at: Acad Science South Africa A S S Af, PO Box 72135, Lynwood Ridge 0040, South Africa (see also Biotechnology).
Our news journalists report that additional information may be obtained by contacting E. Mortimer, University of Cape Town, Inst Infect Dis & Mol Med, Fac Hlth Sci, ZA-7925 Cape Town, South Africa. Additional authors for this research include I.I. Hitzeroth, A. Buys, S. Mbewana and E.P. Rybicki.
Keywords for this news article include: Biotechnology, Cape Town, Viral DNA, RNA Viruses, South Africa, DNA Research, DNA Vaccines, Orthomyxoviridae, Synthetic Vaccines, Vertebrate Viruses, Influenza A Virus Subtype H5N1
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