By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Hypertrophy is the subject of a report. According to news originating from Chapel Hill, North Carolina, by NewsRx correspondents, research stated, "The carboxyl terminus of Hsp70-interacting protein (CHIP) is a ubiquitin ligase/cochaperone critical for the maintenance of cardiac function. Mice lacking CHIP (CHIP-/-) suffer decreased survival, enhanced myocardial injury and increased arrhythmias compared with wild-type controls following challenge with cardiac ischaemia reperfusion injury."
Our news journalists obtained a quote from the research from the University of North Carolina, "Recent evidence implicates a role for CHIP in chaperone-assisted selective autophagy, a process that is associated with exercise-induced cardioprotection. To determine whether CHIP is involved in cardiac autophagy, we challenged CHIP-/- mice with voluntary exercise. CHIP-/- mice respond to exercise with an enhanced autophagic response that is associated with an exaggerated cardiac hypertrophy phenotype. No impairment of function was identified in the CHIP-/- mice by serial echocardiography over the 5weeks of running, indicating that the cardiac hypertrophy was physiologic not pathologic in nature. It was further determined that CHIP plays a role in inhibiting Akt signalling and autophagy determined by autophagic flux in cardiomyocytes and in the intact heart."
According to the news editors, the research concluded: "Taken together, cardiac CHIP appears to play a role in regulating autophagy during the development of cardiac hypertrophy, possibly by its role in supporting Akt signalling, induced by voluntary running in vivo."
For more information on this research see: Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise. Cell Biochemistry and Function, 2013;31(8):724-735. Cell Biochemistry and Function can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Cell Biochemistry and Function - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0844)
The news correspondents report that additional information may be obtained from M.S. Willis, University of North Carolina, Div Cardiol, Chapel Hill, NC 27599, United States. Additional authors for this research include J.N. Min, S. Wang, H. McDonough, P. Lockyer, K.M. Wadosky and C. Patterson (see also Hypertrophy).
Keywords for this news article include: Cardiology, Chapel Hill, Hypertrophy, United States, Protein Chips, North Carolina, Nanotechnology, Emerging Technologies, North and Central America
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