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United States : AGREEMENT to develop new TB vaccines signed by NIBIO, Aeras and Create Vaccine

January 31, 2014

A collaboration agreement for the preclinical and clinical development of new mucosal tuberculosis (TB) vaccines based on NIBIO s human parainfluenza type?2 (rhPIV2) vector technology is signed by the National Institute of Biomedical Innovation of Japan (NIBIO), Aeras, and Create Vaccine.

The collaboration will move forward vaccine candidates based on the rhPIV2 technology through preclinical stages with a plan to advance to safety and immunogenicity testing in clinical trials.

NIBIO, Aeras, and Create Vaccine under the agreement will work together jointly to set up development criteria and assess progress through agreed upon development milestones.

This will comprise the characterization of new vaccine constructs with a variety of antigens, the conduct of immunology studies to identify the most promising novel vaccines and the establishment of current good manufacturing practices (cGMP).

The partners will team up jointly to set up development criteria and assess progress through decided upon development milestones.

The collaboration agreement, which was inked on 26 December 2013, is supported through a generous grant from the Global Health Innovative Technology Fund (GHIT). Tsukuba Primate Research Center at NIBIO has created the vaccine platform.

Create, a joint venture company between Dainippon Sumitomo Pharma and Japan BCG Laboratory, has been formed to develop and market TB vaccines developed in partnership with NIBIO and Aeras. Aeras president and CEO Dr Tom Evans mentioned that these will be important candidates; designed to target mucous membranes to keep TB from entering the lungs.

Dr Evans added, "This type of collaboration among global experts is exactly the approach needed to find an effective vaccine that will end tuberculosis in Japan and around the world .

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Source: TendersInfo (India)

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