News Column

Researchers from Basque Foundation for Science Report Findings in Proinsulin

February 7, 2014



By a News Reporter-Staff News Editor at Science Letter -- New research on Peptide Proteins is the subject of a report. According to news originating from Bilbao, Spain, by NewsRx correspondents, research stated, "Mid-infrared spectroscopy is a widely used tool for material identification and secondary structure analysis in chemistry, biology and biochemistry. However, the diffraction limit prevents nanoscale protein studies."

Our news journalists obtained a quote from the research from Basque Foundation for Science, "Here we introduce mapping of protein structure with 30 nm lateral resolution and sensitivity to individual protein complexes by Fourier transform infrared nanospectroscopy (nano-FTIR). We present local broadband spectra of one virus, ferritin complexes, purple membranes and insulin aggregates, which can be interpreted in terms of their a-helical and/or beta-sheet structure. Applying nano-FTIR for studying insulin fibrils-a model system widely used in neurodegenerative disease research-we find clear evidence that 3-nm-thin amyloid-like fibrils contain a large amount of alpha-helical structure. This reveals the surprisingly high level of protein organization in the fibril's periphery, which might explain why fibrils associate."

According to the news editors, the research concluded: "We envision a wide application potential of nano-FTIR, including cellular receptor in vitro mapping and analysis of proteins within quaternary structures."

For more information on this research see: Structural analysis and mapping of individual protein complexes by infrared nanospectroscopy. Nature Communications, 2013;4():73-81. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Nature Communications - www.nature.com/ncomms/)

The news correspondents report that additional information may be obtained from I. Amenabar, Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain. Additional authors for this research include S. Poly, W. Nuansing, E.H. Hubrich, A.A. Govyadinov, F. Huth, R. Krutokhvostov, L.B. Zhang, M. Knez, J. Heberle, A.M. Bittner and R. Hillenbrand (see also Peptide Proteins).

Keywords for this news article include: Spain, Bilbao, Europe, Peptide Proteins

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Source: Science Letter


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