By a News Reporter-Staff News Editor at Science Letter -- Current study results on Science have been published. According to news reporting originating from Pittsburgh, Pennsylvania, by NewsRx correspondents, research stated, "Using dissipative particle dynamics (DPD) simulations, we model the interaction between nanoscopic lipid vesicles and Janus nanoparticles localized on an adhesive substrate in the presence of an imposed flow. The system is immersed in a hydrophilic solution, and the hydrophilic substrate contains nanoscopic trenches, which are either stepor wedge-shaped."
Our news editors obtained a quote from the research from the University of Pittsburgh, "The fluid-driven vesicle successfully picks up Janus particles on the substrate, transports these particles as cargo along the surface, and then drops off the particles into the trenches. For Janus particles with a relatively large hydrophobic region, lipids from the bilayer membrane become detached from the vesicle and bound to the hydrophobic domain of the deposited particle. While the detachment of these lipids rips the vesicle, it provides a coating that effectively shields the hydrophobic portion of the nanoparticle outer solution. After the particle has been dropped off, the torn vesicle undergoes structural rearrangement, reforming into a closed structure that resembles its original shape. In effect, the vesicle displays pronounced adaptive behavior, shedding lipids to form a protective coating around the particle and undergoing a self-healing process after the particle has been deposited. This responsive, adaptive behavior is observed in cases involving both the step- and wedge-shaped trenches, but the step trench is more effective at inducing particle drop off."
According to the news editors, the research concluded: "The results reveal that the introduction of grooves or trenches into a hydrophilic surface can facilitate the targeted delivery of amphiphilic particles by self-healing vesicles, which could be used for successive delivery events."
For more information on this research see: Self-Healing Vesicles Deposit Lipid-Coated Janus Particles into Nanoscopic Trenches. Langmuir, 2013;29(52):16066-16074. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
The news editors report that additional information may be obtained by contacting X. Yong, University of Pittsburgh, Dept. of Chem Engn, Pittsburgh, PA 15261, United States. Additional authors for this research include E.J. Crabb, N.M. Moellers and A.C. Balazs (see also Science).
Keywords for this news article include: Science, Pittsburgh, Pennsylvania, United States, North and Central America
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