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Researchers at Bharathidasan University Target Biological Pigments

February 7, 2014

By a News Reporter-Staff News Editor at Science Letter -- Current study results on Biological Factors have been published. According to news reporting from Tamil Nadu, India, by NewsRx journalists, research stated, "In this article, we describe a new platform for probing double stranded DNA (dsDNA) by tracing the 'on-off-on' fluorescence signals of quantum dots-cationic porphyrin utilizing fluorescence and synchronous fluorescence measurements. Electrostatic interaction between the negatively charged thioglycolic acid capped CdTe quantum dots (CdTe-TGA QDs) and positively charged porphyrin surfaces leads to drastic quenching (turning off) of the donor by an effective electron transfer process."

The news correspondents obtained a quote from the research from Bharathidasan University, "Interestingly, after the addition of calf thymus DNA (CtDNA), the porphyrins peel off from the quantum dot surface and bind to dsDNA, resulting in the restoration of fluorescence intensity of quantum dots (turning on). Consequently, this can be utilized for the selective sensing of dsDNA via optical responses. Experimental results show that the increase in fluorescence intensity is proportional to the concentration of CtDNA within the range of 6.5 x 10(-9) M to 29.6 x 10(-8) M under the optimized experimental conditions."

According to the news reporters, the research concluded: "Furthermore, the peel off mechanism was confirmed by atomic force measurement."

For more information on this research see: "Turn-on-off-on" fluorescence switching of quantum dots-cationic porphyrin nanohybrid: a sensor for DNA. Analyst, 2014;139(1):225-34. (Royal Society of Chemistry -; Analyst -

Our news journalists report that additional information may be obtained by contacting E. Vaishnavi, School of Chemistry, Bharathidasan University, Tiruchirappalli-620 024, Tamil Nadu, India (see also Biological Factors).

Keywords for this news article include: Asia, India, Tamil Nadu, Porphyrins, DNA Research, Quantum Dots, Nanotechnology, Quantum Physics, Biological Factors, Biological Pigments, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Science Letter

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