By a News Reporter-Staff News Editor at Science Letter -- New research on Science is the subject of a report. According to news reporting out of Jinan, People's Republic of China, by NewsRx editors, research stated, "A novel strategy for selective and sensitive amperometric detection of lead ion (Pb(2+)) was proposed based on target-induced strand release. The underlying gold electrode was pre-modified with dendritic gold nanoparticles by direct electrodeposition to afford increased electrode surface area for immobilization of thiol group-containing capture DNA molecules."
Our news journalists obtained a quote from the research from Shandong Normal University, "The hybridization of the capture DNA molecules with Pb(2+)-specific aptamer molecules to form a DNA duplex, into which methylene blue was intercalated, induced measurable electrochemical signal. Upon addition of Pb(2+), it could specifically bind to its aptamer to form Pb(2+)-stablized G-quadruplex and induce the aptamer strand to release from the electrode surface into solution, accompanied by the release of intercalated MB responsible for significant signal reduction. The fabricated biosensor showed a linear response to the logarithm of Pb(2+) concentration over the range of 1.0 x 10(-10) M to 1.0 x 10(-7) M with a detection limit of 7.5 x 10(-11) M. In addition, this strategy afforded an exquisite selectivity for Pb(2+) against other metal ions."
According to the news editors, the research concluded: "The excellent sensitivity and selectivity show good potential for Pb(2+) detection in real environmental samples."
For more information on this research see: A selective amperometric sensing platform for lead based on target-induced strand release. Analyst, 2013;138(2):461-6. (Royal Society of Chemistry - www.rsc.org/; Analyst - pubs.rsc.org/en/journals/journalissues/an)
Our news journalists report that additional information may be obtained by contacting F. Li, College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, People's Taiwan. Additional authors for this research include L. Yang, M. Chen, P. Li and B. Tang (see also Science).
Keywords for this news article include: Asia, Jinan, Science, People's Republic of China.
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