By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Fresh data on Biotechnology are presented in a new report. According to news reporting from Zhengzhou, People's Republic of China, by NewsRx journalists, research stated, "TRAF4 is an adapter protein overexpressed in certain cancers, but its contributions to tumorigenesis are unclear. In lung cancer cells and primary lung tumors, we found that TRAF4 is overexpressed."
The news correspondents obtained a quote from the research from Zhengzhou University, "RNA interference-mediated attenuation of TRAF4 expression blunted the malignant phenotype in this setting, exerting inhibitory effects on cell proliferation, anchorage-independent growth, and tumor development in a xenograft mouse model. Unexpectedly, we discovered that TRAF4, but not Skp2, was required for activation of the pivotal cell survival kinase Akt through ubiquitination. Furthermore, TRAF4 attenuation impaired glucose metabolism by inhibiting expression of Glut1 and HK2 mediated by the Akt pathway."
According to the news reporters, the research concluded: "Overall, our work suggests that TRAF4 offers a candidate molecular target for lung cancer prevention and therapy."
For more information on this research see: TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer. Cancer Research, 2013;73(23):6938-6950. Cancer Research can be contacted at: Amer Assoc Cancer Research, 615 Chestnut St, 17TH Floor, Philadelphia, PA 19106-4404, USA. (American Association for Cancer Research - www.aacr.com; Cancer Research - cancerres.aacrjournals.org/)
Our news journalists report that additional information may be obtained by contacting W. Li, Zhengzhou Univ, Basic Med Sch, Zhengzhou 450052, Henan, People's Republic of China. Additional authors for this research include C. Peng, M.H. Lee, D. Lim, F. Zhu, Y. Fu, G. Yang, Y.Q. Sheng, L.B. Xiao, X. Dong, W.Y. Ma, A.M. Bode, Y. Cao and Z.G. Dong (see also Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Oncology, Zhengzhou, Lung Cancer, Lung Neoplasms, Cancer Gene Therapy, People's Republic of China
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