By a News Reporter-Staff News Editor at Cardiovascular Week -- Research findings on Endothelial Cells are discussed in a new report. According to news originating from Manchester, United Kingdom, by NewsRx correspondents, research stated, "Background and ObjectiveCoronary stents have been widely used in the treatment of coronary heart disease. However, complications have hampered the long-term success of the device."
Our news journalists obtained a quote from the research from the University of Manchester, "Bare-metal stents (BMS) have a high rate of restenosis and poor endothelialisation. The drug-eluting stents (DES), although dramatically reduce restenosis, significantly prevent endothelialisation leading to late thrombosis and behave the same way as BMS after drug releasing. Rapid adhesion and growth of endothelial cells on the stent surface is a key process for early vascular healing after coronary stenting which contributes to the reduction of major complications. Surface properties manipulate cell growth and directly determine the success and life-span of the implants. However, the ideal surface properties of coronary stents are not yet fully understood. The objective of this research is to understand how surface micro/nano textures and associated material chemistry changes generated by a laser beam affect the behavior of endothelial cells on bare metal 316L stents. Materials and MethodsA high power laser beam was applied to modifying the surface properties of 316L coronary stent material and the commercial coronary stents, followed by examination of the adhesion and proliferation of human coronary endothelial cells that were growing on the surfaces. Surface properties were examined by scanning electron microscopy, contact angle measurement, and X-ray photoelectron spectroscopy. ResultsA novel surface with combined micro/nano features was created on stent material 316L and coronary stent with a specific surface chemistry. This surface gives rise to a threefold increase in the adhesion and eightfold increase in the proliferation of endothelial cells. Interestingly, such effects were only observed when the surface texture was produced in the nitrogen atmosphere suggesting the importance of the surface chemistry, including the dramatic increase of chromium nitride, for the interaction of endothelial cells with the material surface. This novel surface is also super-hydrophilic with close to zero water/cell culture fluid contact angles and low cytotoxicity. ConclusionsA novel surface created by laser surface-engineering with a combination of defined surface texture and surface chemistry was found beneficial for the improvement of coronary stent endothelialisation."
According to the news editors, the research concluded: "The technology presented here could work with both DES and BMS with added benefit for the improvement of the biocompatibility of current coronary stents. Lasers Surg. Med. 45:608-616, 2013."
For more information on this research see: Enhancement of Endothelialisation of Coronary Stents by Laser Surface Engineering. Lasers in Surgery and Medicine, 2013;45(9):608-616. Lasers in Surgery and Medicine can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Lasers in Surgery and Medicine - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1096-9101)
The news correspondents report that additional information may be obtained from L. Li, University of Manchester, Sch Mat, Center Corros & Protect, Manchester M13 9PT, Lancs, United Kingdom. Additional authors for this research include N. Mirhosseini, A. Michael, Z. Liu and T. Wang (see also Endothelial Cells).
Keywords for this news article include: Europe, Chemicals, Chemistry, Manchester, Engineering, United Kingdom, Endothelial Cells
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