News Column

Study Results from Royal Prince Alfred Hospital Provide New Insights into Immunology

February 6, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Current study results on Life Science Research have been published. According to news reporting originating from Sydney, Australia, by NewsRx correspondents, research stated, "The tolerogenic properties of the liver have long been recognised, especially in regard to transplantation. Spontaneous acceptance of liver grafts occurs in a number of experimental models and also in a proportion of clinical transplant recipients."

Our news editors obtained a quote from the research from Royal Prince Alfred Hospital, "Liver graft acceptance results from donor antigen-specific tolerance, demonstrated by the extension of tolerance to other grafts of donor origin. A number of factors have been proposed to be involved in liver transplant tolerance induction, including the release of soluble major histocompatibility (MHC) molecules from the liver, its complement of immunosuppressive donor leucocytes, and the ability of hepatocytes to directly interact with and destroy antigen-specific T cells. The large tissue mass of the liver has also been suggested to act as a cytokine sink, with the potential to exhaust the immune response. In this review, we outline the growing body of evidence, from experimental models and clinical transplantation, which supports a role for large tissue mass and high antigen dose in the induction of tolerance."

According to the news editors, the research concluded: "We also discuss a novel gene therapy approach to exploit this dose effect and induce antigen-specific tolerance robust enough to overcome a primed T cell memory response."

For more information on this research see: Liver transplant tolerance and its application to the clinic: can we exploit the high dose effect? Clinical and Developmental Immunology, 2013;2013():419692. (Hindawi Publishing -; Clinical and Developmental Immunology -

The news editors report that additional information may be obtained by contacting E.C. Cunningham, Collaborative Transplantation Research Group, Bosch Institute, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW 2006, Australia. Additional authors for this research include A.F. Sharland and G.A Bishop (see also Life Science Research).

Keywords for this news article include: Biotechnology, Sydney, Gene Therapy, Bioengineering, Life Science Research, Australia and New Zealand.

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Source: Gene Therapy Weekly

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