By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Optical Coherence Tomography. According to news reporting originating from Madrid, Spain, by NewsRx correspondents, research stated, "To analyze corneal and total aberrations using custom-developed anterior segment spectral optical coherence tomography (OCT) and laser ray tracing in keratoconic eyes implanted with intracorneal ring segments (ICRS). Evaluation of technology. Prospective study. Case series."
Our news editors obtained a quote from the research from Jimenez Diaz Foundation, "Nineteen keratoconic eyes were measured before and after ICRS surgery. Anterior and posterior corneal topographic and pachymetric maps were obtained pre- and postoperatively from 3-dimensional OCT images of the anterior segment, following automatic image analysis and distortion correction. The pupil center coordinates were used as reference for estimation of corneal aberrations. Corneal aberrations were estimated by computational ray tracing on the anterior and posterior corneal surfaces. Total aberrations were measured using a customt-developed laser ray tracing aberrometer. Corneal and total aberrations were compared in 8 eyes pre- and postoperatively for 4-mm pupils. Total and corneal aberrations were highly correlated. Average root mean square of corneal and total high-order aberrations (HOAs) were 0.78 +/- 0.35 mu m and 0.57 +/- 0.39 mu m preoperatively, and 0.88 +/- 0.36 mu m and 0.53 +/- 0.24 mu m postoperatively (4-mm pupils). The anterior corneal surface aberrations were partially compensated by the posterior corneal surface aberrations (by 8.3% preoperatively and 4.1% postoperatively). Astigmatism was 2.03 +/- 1.11 mu m preoperatively and 1.60 +/- 0.94 mu m postoperatively. The dominant HOA aberrations both pre- and postoperatively were vertical coma (Z(3)(-1)), vertical trefoil (Z(3)(-3)), and secondary astigmatism (Z(4)(4)). ICRS decreased corneal astigmatism by 27% and corneal coma by 5%, but on average, the overall amount of HOA did not decrease significantly with ICRS treatment. OCT is a reproducible technique to evaluate corneal aberrations. OCT-based corneal aberrations and ocular aberrations show a high correspondence in keratoconic patients before and after ICRS implantation."
According to the news editors, the research concluded: "ICRS produced a decrease in astigmatism, but on average did not produce a consistent decrease of HOAs."
For more information on this research see: Ocular and Optical Coherence Tomography-Based Corneal Aberrometry in Keratoconic Eyes Treated by Intracorneal Ring Segments. American Journal of Ophthalmology, 2014;157(1):116-127. American Journal of Ophthalmology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; American Journal of Ophthalmology - www.elsevier.com/wps/product/cws_home/601028)
The news editors report that additional information may be obtained by contacting P. Perez-Merino, Fdn Jimenez Diaz, E-28040 Madrid, Spain. Additional authors for this research include S. Ortiz, N. Alejandre, A. De Castro, I. Jimenez-Alfaro and S. Marcos (see also Optical Coherence Tomography).
Keywords for this news article include: Spain, Madrid, Europe, Imaging Technology, Clinical Trials and Studies, Optical Coherence Tomography
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