By a News Reporter-Staff News Editor at Insurance Weekly News -- Investigators discuss new findings in Risk Management. According to news originating from Research Triangle Park, North Carolina , by VerticalNews correspondents, research stated, "The benchmark dose (BMD) approach has gained acceptance as a valuable risk assessment tool, but risk assessors still face significant challenges associated with selecting an appropriate BMD/BMDL estimate from the results of a set of acceptable dose-response models. Current approaches do not explicitly address model uncertainty, and there is an existing need to more fully inform health risk assessors in this regard." Our news journalists obtained a quote from the research from Environmental Protection Agency , "In this study, a Bayesian model averaging (BMA) BMD estimation method taking model uncertainty into account is proposed as an alternative to current BMD estimation approaches for continuous data. Using the hybrid method proposed by Crump, two strategies of BMA, including both maximum likelihood estimation based and Markov Chain Monte Carlo based methods, are first applied as a demonstration to calculate model averaged BMD estimates from real continuous dose-response data. The outcomes from the example data sets examined suggest that the BMA BMD estimates have higher reliability than the estimates from the individual models with highest posterior weight in terms of higher BMDL and smaller 90th percentile intervals. In addition, a simulation study is performed to evaluate the accuracy of the BMA BMD estimator. The results from the simulation study recommend that the BMA BMD estimates have smaller bias than the BMDs selected using other criteria." According to the news editors, the research concluded: "To further validate the BMA method, some technical issues, including the selection of models and the use of bootstrap methods for BMDL derivation, need further investigation over a more extensive, representative set of dose-response data." For more information on this research see: Model Uncertainty and Bayesian Model Averaged Benchmark Dose Estimation for Continuous Data. Risk Analysis , 2014;34(1):101-120. Risk Analysis can be contacted at: Wiley-Blackwell, 111 River St , Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/ ; Risk Analysis - onlinelibrary.wiley.com/journal/10.1111/ (ISSN)1539-6924) The news correspondents report that additional information may be obtained from K. Shao , Environmental Protection Agency , Natl Center Environm Assessment, Res Triangle Pk, NC 27711, United States . Keywords for this news article include: United States , North Carolina , Risk Management, Research Triangle Park , North and Central America Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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